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One issue with self-hosted is that your ISP may block SMTP or worse they add their customer IP blocks to spam blacklists.

I think ISPs should firewall SMTP by default, and if they don't provide you with static IP they absolutely should add their dynamic IP blocks to the DUL / PBL etc. Almost all of the spam rejects from my mail server are from dynamic IPs. Them's the breaks. FWIW my ISP were perfectly happy to relax the firewall rules when I asked.

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