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Not to my knowledge. I always use Emacs in terminal mode even when I have a window system available and I have never encountered anything that would only work with a GUI. I think there are some extensions that work only with a GUI but that's not an inherent limitation of Emacs and there are usually a ton of alternatives.

Auctex mode gives you graphical previews of your LaTeX documents. That would be hard to do in a terminal.

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