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Postini.com (Google), Forefront (Exchange), and Barracuda Networks are some products/vendors in the space - its a whole industry. Just Google around a bit for "server side spam filtering" and such.

Anecdote: we use hosted Exchange from Microsoft. I tried to setup a cron job to email us all at 4:57 with the subject line "Get The Fuck Out". Those don't come through either.

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