One caveat to add about css animations. I learned last night that animations don't respect fractional pixel values, so if you want to move something very slowly, like moving an image 10px over 2 seconds, the animation will be very jerky, and you need to use canvas to get the desired effect.
By leveraging LESS or SASS you can create mixins which handle the vendor prefixing for you. For those new to LESS or SASS, the addition will require you to update your workflow a bit to compile the syntax down to vanilla CSS. This minimal impact though is far outweighed by the benefits of managing less style rules in your LESS or SASS file(s).