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$49 Personal Genome at 23andme (incognito windows until you get the best price) (23andme.com)
45 points by bsimpson 1011 days ago | 74 comments



Run in your JavaScript console:

  document.cookie = 'optimizelyBuckets=' + escape('{"145285685":"145865258"}') + '; domain=.23andme.com'; document.location.reload(true);
The other values I found:

  69 -> escape('{"145285685":"145818631"}')
  99 -> escape('{"145285685":"145866265"}')
  149 -> escape('{"145285685":"145285686"}')
  299 -> escape('{"145285685":"145891045"}')
Edit: Actually, it looks like this no longer works. They may have noticed and stopped the A/B test.

You can empty the cart and run

  window.$.ajax({url:'/special_offer/49NOV2012/?json=true'})
Then click add to cart and once in your cart it will be $49.

I'm going to have to start looking at more websites' Optimizely codes!

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This works:

https://www.23andme.com/special_offer/49NOV2012/

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Doesn't seem to work anymore. Had to break eventually I guess!

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Damn, none of these methods are working for me anymore...

Anyone else having any luck?

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Everyone is so fixated on the price.

What I want to know is, who they share the data with? Do the insurance companies get our genome?

Come on people, there should be no more precious data to you, than the genome of you and your family. Yet facebook users seem more concerned about their social network privacy than HN members are about their genome privacy.

For insurance companies, this could be a total actuarial GOLDMINE and it would probably even be worth them paying us for the data.

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>What I want to know is, who they share the data with?

Did you read the privacy policy? Specifically:

https://customercare.23andme.com/entries/21262376-how-is-the...

23andMe research may involve collaboration with external parties; however, these external parties will only have access to pooled data stripped of identifying information. 23andMe will never release your individual-level data to any third party without asking for and receiving your explicit authorization to do so. As part of our commitment to protecting the privacy of our research participants, we have also obtained a Certificate of Confidentiality from the U.S. Department of Health and Human Services. This certificate allows 23andMe to protect research participants’ data from involuntary disclosure, including subpoenas from federal, state, and local authorities.

>Do the insurance companies get our genome?

They're not allowed to discriminate based on genetic predisposition, and based on the privacy policy, they're not going to get that info anyways.

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Thank you for finding that, Karunamon.

It is nice that their website includes reassuring language. But really, how stable is that policy in the face of changing corporate owners, changing political administration (romney?), changing supreme court justices, changing geopolitics?

Genome data is of permanent importance. To be able to, even in 50 years, look back at genome records of today, will still be very valuable (especially when combined with genealogy records...).

Look at privacy trends, storage trends, and trends in govt accountability and transparency. Make no mistake, once our sequences are in corporate databases, there is no going back.

I look forward to user-driven cryptographic genome tools, which will allow us to inspect our own genomes, while maintaining personal control over our entire genome (ie., never having to hand the whole sequence over to a commercial or govt entity).

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>But really, how stable is that policy in the face of changing corporate owners, changing political administration (romney?), changing supreme court justices, changing geopolitics?

That's a valid point, but a few things reassure me. Firstly that confidentiality cert from DHHS probably isn't going to be made useless by a political entity any time soon (and I'd assume, though would need to research, that such a cert would also apply to any buyers should 23AM get picked up by someone else, and probably carries some requirements for them as well)

Even then, I doubt within the next 60 or so years left on my lifespan that there will be any shenanigans in that area... and after I'm gone, they can do whatever the hell they want with my sequence :)

I'd imagine that, given enough time and cost reduction, services like this will become nationalized, where your genome is sequenced at birth for identity and health purposes.

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BTW Full Privacy Policy is here

https://www.23andme.com/about/privacy/#Full

It's pretty clear on what they choose to share.

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It's OK. Nobody gets your genome. It would be suicidal for them to share, plus there are laws on the books (GINA at the federal level, a stronger law recently passed in CA).

Also, quite a few people have been posting their data openly, for example here: http://opensnp.org/ . So far I am not aware of any adverse effects. Not saying there won't be any ever, but I would be a lot more paranoid about my browser history.

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The Genetic Information Nondiscrimination Act[1] was passed 4 years ago. It makes it illegal for insurance companies and employers to discriminate based on genetic information.

In the long-term, it's unlikely that you'll be able hide your genome. Sequencing technology is only going to get cheaper and more advanced. People slough off cells like crazy. You'll have to live in a spacesuit if you want to avoid leaving your genetic information everywhere.

1. http://en.wikipedia.org/wiki/Genetic_Information_Nondiscrimi...

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Note that in 13 months (in the US) pre-existing conditions will no longer be excludable (subject to a few complexities, yada yada). That rules out the worst potential abuse. It's unclear to me how "insurance company" access to this data would even be an inarguably bad thing. I can see a lot of good resource planning that could come from a large body of genome data.

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Yeah, you're right. Though I'm generally curious and I'd like to know more about this part of me, scientifically. Is there some other way I can find that?

And as for insurance, I think that applies in the US where insurance companies are, well, evil. In AU, or CAN or some other country where medicine is provided to everyone, this actually seems like GOOD information to have on hand.

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Verified to work. http://i.imgur.com/6JqbL.png?1

I had to keep closing and creating a new incognito window, not just new tabs.

It's cheaper to create a new account then to upgrade my old account for $249.

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Indeed it is cheaper to just get this at $49 than upgrade for $249. This is a great way to upgrade to the V3 chip.

You get more SNPs if you have V2 and they add in V3, so I'll call them and see if I can link it to my account.

Here are the SNP counts per chip version combo:

V2 only: 576,000 SNPs V3 only: 967,000 SNPs V2 + V3 (upgraded): 996,000 SNPs

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Looks like maybe they are doing some A/B testing based on the way this site responds. Regardless $49 instead of $299 (The first price I got in incognito) is extremely significant.

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I think their test results are going to be a bit biased!

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I think it's an A/B test as well. I saw $49, $149 and $299.

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I have seen $69 and $99 as well.

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Perhaps it is an A/B/C/D/E/F/G/H test...

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This is ridiculous. While signing up, I got this message (I hate my state sometimes...):

""" 23andMe is currently unable to process saliva samples collected in or mailed from the state of New York. The New York Department of Health considers our Personal Genome Service a test requiring a lab license and direct physician involvement.

If you or the recipient of the Spit Kit intend to collect your sample and mail it from outside the state of New York, please select the "Ship to New York" button below. Upon receipt of your Spit Kit, you or the Spit Kit recipient will be required to affirm under penalty of law that the sample for the Spit Kit has not been collected in or mailed from the state of New York."""

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If you want to skip this step you can enter a different state and it should still get to you. (zip code > state code) It's worked for me at least.

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Great find. I suppose this is either a glitch or maybe they're doing some sort of pricing experimentation. Either way, my father has been wanting to do this for a while so I think $49 seals the deal!

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That would be some glitch :) But no, it's the latter.

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Yep, running tests with Optimizely. Surely they have updated it by now.

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Alternatively, you can simply delete cookies and refresh. This is likely going to be impractical if you don't have a cookie-management extension.

I use this:

https://chrome.google.com/webstore/detail/edit-this-cookie/f...

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I thought it was interesting that I saw the full price flash on the screen briefly before I saw my discounted price so I looked into the JS and sure enough they are swapping out offer urls that look like this: /special_offer/49NOV2012/?json=true

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I wonder what their threshold is for offering this as the permanent price? I know I've never considered it before b/c of the price. Heck, I didn't consider it when I got the $99 offer. But when I got $49, I ordered two.

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It used to be back when the $299 price was offered that you had to pay $99 for a year of subscription to their annotation updates, not sure what's going on now.

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Hmmm...not sure I'd care about the updates nearly as much as the initial profile. Does anyone see value from the updates? What kind of information do those provide?

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I just bought the kit for Australia - it was $49 + $74 shipping, the updates are _not_ included - in fact, I think they stopped offering these.

The value used to be that you get the newest research linked to your SNPs, i.e., if there's a new publication on one of your variations you would have been notified.

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Our bias-ridden mammalian brains can't really cope with these things in a reasonable way. Although I've been considering this for $299 for quite some time it feels like a total rip off right now

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Maybe I've been watching too much Dexter, but isn't this a law enforcement agency's dream? Never again will they fail to get a match on DNA, just subpoena 23andme and competitors.

Right?

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Nope. Someone posted a link above[1] to what I assume is a 23andme FAQ response, stating that they have a Certificate of Confidentiality from the (US) government.

According to this NIH page on said certificates[2], it sounds like even if they were served a subpoena for the information, 23andme could still tell them to fuck off.

[1] https://customercare.23andme.com/entries/21262376-how-is-the...

[2] http://grants.nih.gov/grants/policy/coc/background.htm

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Wow, they are charging $115 shipping to Australia for two kits.

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To be fair, the charge includes both shipping the kits to you and for you to ship the kits back to them, so the price isn't as bad as it looks. But I do agree with you that it can be lower.

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And customs duties. They are not trying to gouge you, AFAIK.

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@Dramatize: but the US might charge them import duties when you send it back. Not sure if the US has a duty-free allowance like we do.

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There won't be duties as it's under $1000. I did realise after that it included the return postage.

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To be fair, that is for return shipping on two kits (you have to send the kit back to them for testing).

That said, hopefully they do some A/B testing on shipping prices next ;)

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Seems like the deal's over. I've now hit the homepage ~50 times with a new incognito window each time and the price was always $299. Too bad, it would've been nice.

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No, it's still working. I just bought two for $49.

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Fyi, I just received the offer.

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Doesn't seem to work anymore. The price I get is $299.

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Keep deleting your cookies OR restart your Firefox in private mode, I had to restart about 7 times until I got the $49 offer.

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Try again.

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Thank you so much for this! I wanted to try it out for a long time, but was waiting for a discount. It was a no brainer at $49 :)

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I've always wanted to do this, but $300 each is too much for my wife and I to both get it done; saw $99 each and bought two.

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As far as I can tell, this is just their usual SNP array product. Wake me up when they offer $49 for 30x coverage.

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They offer a full exome sequencing for $999 in a pilot right now, so for a full genome 30x sequencing for 50 bucks you might have to sleep a decade or so

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Nah, I think it will be less than 10 years. But it is very weird to call their SNP product a "personal genome". This whole thread is full of crazy. :/

Edit: ftp://ftp.1000genomes.ebi.ac.uk/vol1/ftp/ <-- gimme this for $49

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Don't know if you're going to see this, but you might be interested:

http://www.genomicslawreport.com/index.php/2012/11/29/dna-dt...

>Whole exomes ($695 at 80x coverage) and genomes ($5,495 at 30x coverage) are both listed as available products.

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I've been wanting to do this for ages and got the $49 on the second try. Much thanks to the poster for this!

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Maryland customers not allowed.

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Yeah, just noticed this when I saw the reasonable $49 price. Really sucks.

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Thank you so much! Ordered!

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I don't see 49. It says 299 for me. In incognito window it is 99.

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New incognitos, not refresh, not new tab

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Not only new incognito windows, but you have to close all incognito windows you have open before opening a new one.

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i just bought 3 for me whole family lol for $49 dollars each. i was provided $69, $99, $199 and $299 multiple times before they gave me $49 dollars.

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I've seen $49, $69, $99, and $299. ABCD price testing!

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Is this still working? All I see is $299

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Just got 3 tests for $49 each. Thanks!

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How much is it usually?

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I think it's usually $199 or $299. (that was the first price I saw)

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300$

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I ordered one for $300 a couple of weeks ago :(

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Still worth it at $300!

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Just picked mine up for $49

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I think this could be a silent Cyber Monday sale. I saw $49/$69/$99/$199/$299.

Got mine for $49. Note once you get $49, you can order multiple kits at that same price point.

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Has anyone done this? If so, was it worth it?

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I did 23andme a year or two ago. I found out I have a really boring genome. No real diseases or unexpected ancestry (I guess I was secretly hoping I was adopted from Russian/Jewish royalty or martians or something?).

It's certainly worth $49 to me to know this (I think I paid $99 under a FNF deal a while ago; I know one of the founders, who is awesome and a great entrepreneur).

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So you're saying they won't sell us down the river? I'm sold

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Yeah, they're pretty decent people. I'm sure if the government went to them with a warrant or something, they'd fully comply, but they genuinely care about privacy and customers, and would be unlikely to do anything evil. They're also rich enough that I doubt they'd be forced into a sale to some crappy entity who would then abuse things, and their privacy policy is decent enough.

The only real risk I see is if your account is compromised somehow, but at least for me, there's nothing so sensitive in my account that I'd care.

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