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In the past (about four years ago) we had a difficult to debug issue which only manifested in IE on one team member's computer - we traced it down to Multiple IE screwing up cookie handling in some odd manner. So you'd be testing with an environment that's not necessarily 100% the same as your end users.

Yes, I have also seen peculiarities with Multiple IE. IMO, it's decent for casual testing, but you still need to do testing on real installations of your target platforms.

...nice to know such things can happen ...but I've never been bitten by it so far :)

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