The one thing that worries me is the xrandr support borked bug. Can anyone comment on xrandr and qtile?
Restarting qtile isn't that bad though because you don't lose your windows, just the layout of them. And because I have my most common layout first, it turns out not to bug me.
For me it just feels right, even with its warts. I'm glad Tycho and others are pushing it forward! I miss it everytime I use a mac or other machines. Plus the kids think at my child's elementary school think my computer is "awesome"! :)
If you like tiling and multiple monitor support, I suggest you check out Wingo.  It's a hybrid window manager written in Go, and configured in simple INI-like files.
Disclaimer: I'm the author.
 - https://github.com/BurntSushi/wingo