The things that I have been thinking a lot about lately are --
What happens when natural death is reduced by 99% and human levels of intelligence are extended to countless genetically customized biological lifeforms?
Do sentient computers that consume non-renewable resources have the right to reproduce and live? Who would enforce either option?
I think we are at the early stages of experiencing a paradigm change in human philosophy. In some part, because much of traditional human beliefs simply hold no foundation with reality (religious and otherwise.) Secondly, the things that were distant science fiction now exist or is within reach. The Star Wars/Star Trek view of the future and space travel mere decades later has become archaic.
I happened to read "The Age of Spiritual Machines" by Ray Kurzweil over a decade ago. It completely changed my thought process in regards to much of life. (I doubt without it I would have been as strongly convicted about dropping out of college and starting an internet business.) As technology has advanced since then, I believe it has kept my thinking a step beyond where it would have been otherwise.
The average person, even equipped with the latest smartphone, is unequipped to deal with these radical changes. Children can no longer look to their parents for patterns on how to live their lives, because their parents lives will not remotely resemble their own.
These are very good opportunities for start ups.
This stands for at least a century when the big shift from the village to the city occured.
I'd say it wasn't any less radical than the shifts ahead us. Maybe a bit more radical even.