That's a hard damn problem. There are some extraordinarily well-funded research groups that are struggling to model any reasonably large number of interactions at that scale. State of the art supercomputing clusters can currently simulate systems of hundreds of thousands of atoms, not even in real-time, and they're still making some assumptions along the way, which might not hold true if you were to arbitrarily modify any fundamental constants.
You could probably write a physics engine that passably pretends to simulate some (non-arbitrary!) changes in fundamental constants. But it would be hard to guess what matter would even look like for different values of, say, Z0.