On: New antibiotic targets IBD and AI predicted how it would work

[FollowingTheDao]

What????

We knew that LolCDE was a vulnerability to e coli since well before 2016 and knew inhibitors of the complex, globomycin being one of them, which they knew about since 1978

https://journals.asm.org/doi/full/10.1128/jb.00502-16

https://pubmed.ncbi.nlm.nih.gov/353012/

Is enterololin just another from of globomycin?

Is AI smart or are scientists just getting dumber?

[raincom → FollowingTheDao]

AI just picked up these references and gave an answer. Scientists in this field should have read these papers instead of relying on AI.

[rdedev → raincom]

From what I understand they used a diffusion model (diffdock) to predict the mechanism. These types of models are not LLMs that need to be trained on text

[D-Coder → raincom]

There are probably 37,392 papers on this. So your "should" is probably just impossible for humans.

[FollowingTheDao → D-Coder]

This is such a ridiculous argument. They could have read five papers, couldn’t they?

[klustregrif → FollowingTheDao]

Picking up five needles is trivial. Picking up five needles in 50000 haystacks is difficult.

[D-Coder → FollowingTheDao]

How do they know which five papers to read?

[nisten → FollowingTheDao]

Yes.