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It would take some careful research to show helpful (if at all) different fonts are for people with reading difficulties, who after all are still going to be in a world full of standard fonts.

Much of the best research on dyslexia is gathered into the very interesting recent book Reading in the Brain: The New Science of How We Read



by Stanislas Dehaene. There are definitely educational approaches that help prevent the development of dyslexia in young readers or that alleviate it in older readers. Cross-national comparisons of reading in different scripts for differing languages, and comparisons of reading performance with differing typefaces for English (both reported on in the book) don't suggest that letter forms are the MAIN issue in dyslexia, although helping readers notice distinct letter shapes is helpful for readers who don't distinguish them. It would be a good idea to use the kind of brain-imagining studies mentioned by Dehaene (a neuroscientist) to test the usefulness of different fonts for readers who are categorized as having dyslexia.

As they say in Chinese, "實事求是" (the standard English translation is "seek truth from facts," which will do for this Hacker News comment), so whatever helps dyslexic persons, more power to it, but test to make sure how helpful it is and to find out what else would be helpful too.

who after all are still going to be in a world full of standard fonts.

That is true, but one of the advantages of electronics/computers over paper is that you could set this entirely as your only font for the web, your ereader etc.

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