Life-changing cream to treat skin cancer moves closer to reality

[giuliomagnifico]

https://www.uq.edu.au/news/article/2024/11/life-changing-cream-treat-skin-cancer-moves-closer-reality

[gus_massa]

It has too few details. It looks like very preliminate research. Clicking here and there, I got this patent https://patentscope.wipo.int/search/en/detail.jsf?docId=WO20... that appears to be a molecule that disrput https://en.wikipedia.org/wiki/Proline#Cis%E2%80%93trans_isom...

[uj8efdjkfdshf]

Having had a look at it, it seems like this involves a molecule (Q2361) closely related to tacrolimus that is capable of binding to FKBP12 where tacrolimus would normally bind but without affecting the function of FKBP12.[1]

This seems to be useful in the specific case of people on long term tacrolimus as it locally antagonises tacrolimus activity in the skin to reduce cancer risk.

[1] https://jitc.bmj.com/content/jitc/11/9/e006783.full.pdf

[pulvinar]

>in organ transplant patients

It doesn't say if this has any effect for non-immunosuppresive-related skin cancer.

[DidYaWipe → pulvinar]

Which is the first question you'd ask. Standard journalistic failure.