It's not just the C spec you've got to watch. I saw a wonderful bug last week where the author hadn't spotted that write(2) returned a ssize_t, not a size_t (or didn't appreciate the difference), so was gleefully checking an unsigned variable for a -1 error result.
How did the bug manifest itself? You can store 0xffffffff(ffffffff) in a 32(64)-bit unsigned int, or a 32(64)-bit signed int. In the one case you'll get UINT_MAX, -1 in the other, but they should compare as equal. If you have -Wextra turned on, gcc will give a warning, though.
Here's some sample C code tested on a 32-bit Linux system: