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From mental point of view, I'd think at least impact on attention and energy levels.

That's aside, of course, from the physical dangers: diabetes (or diabetes like symptoms), very serious weight gain. That also applied to all carbs, not just sugars but some carbs are worse than others (e.g. high fructose corn syrup, white bread) while some are better (brown rice, whole wheat).

Put simply, simple sugars can screw with mood. Better to avoid them in general. This doesn't mean you shouldn't eat that brownie. It means you shouldn't eat them often or eat a lot of them.

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