I like QuickBase for prototyping and departmental applications but it does have it's idiosyncrasies. Unfortunately, I don't get to use it much anymore because I am bootstrapping a startup and it is too expensive (not free enough) for us. If we start scaling I will use QuickBase to automate as much as possible.
I have a working DBAPI compliant Python module that is about 40% complete. It really needs a method to translate SQL to QuickBase's clunky xml query format. The Ruby API has one and it would be trivial to port it to Python.
Would you (or anyone else?) be interested in contributing if I put it up on GitHub?