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I highly recommend anyone who is interested in this subject read Aubrey de Grey's book on the current state of the science of biogerontology: http://www.amazon.com/Ending-Aging-Rejuvenation-Breakthrough...

It's interesting, thorough, and optimistic. I also recommend donating money to SENS, as this cause is dramatically underfunded relative to its realistic potential to save and enhance human life for everyone. http://sens.org/

Also strongly recommended: read the SENS Foundation 2011 annual and research reports, which outline for the layperson (while giving details for the scientist) exactly what biotechnologies the Foundation and its allies are working on, where present progress stands, and how mature versions of these technologies can be used to reverse aging.


"We are delighted that SENS Foundation was able to make expenditures of $1,518,000 in 2011. This was an increase of over $400,000 from 2010, overwhelmingly in support of direct research and conference projects. ... We greatly appreciate the support of the many individuals who contributed to our mission. We would like to thank Peter Thiel, Jason Hope, the Methuselah Foundation, and all of our contributors and volunteers for their on-going generosity. We expect a significant increase in both revenues and expenses for 2012, as we begin to see distributions from a de Grey family trust, under a grant from SENSF-UK. This support will be in addition to the contributions we receive from other sources."


"The elasticity of the artery wall, the flexibility of the lens of the eye, and the high tensile strength of the ligaments are examples of tissues that rely on maintaining their proper structure. But chemical reactions with other molecules in the extracellular space occasionally result in a chemical bond (a so-called crosslink) between two nearby proteins that were previously free-moving, impairing their ability to slide across or along each other and thereby impairing function. It is the goal of this project to identify chemicals that can react with these crosslinks and break them without reacting with anything that we don't want to break.

"In 2011, we established a Center of Excellence for GlycoSENS and other rejuvenation research at Cambridge University and hired postdoctoral student Rhian Grainger to design and perform experiments to develop reagents that can detect proteins bearing glucosepane crosslinks, facilitating further studies on its structure, abundance, and cleavage by small molecules. We also established a collaboration with researchers at Yale University, who will lend their expertise in generating advanced glycation end-products and lead efforts in developing agents which may be able to cleave glucosepane."

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