I never use fink, macports or homebrew to install on my Mac. It's pretty much download source, take a look at the README/INSTALL and go from there.
The main issue is that Mac is probably not the usual target system for these builds (in comparison to a mainstream Linux distro). And as such differences in the version of the compiler, the set of libraries, installed dev tools, etc. may lead to build issues. You might have to download a few more things or know to add or override compiler or link flags.
Even with the latest Ubuntu or Fedora distro, you still run into having to know that you might need to install dev files to get a build from source to work (recent example for me is pcre libs for nginx).