Unless you use Dvorak. I know I'm in a super minority here. But shortcuts based on keyboard location rather than tied to some mnemonic are damn near impossible to get right. Doubly so when I have to switch to QWERTY to work with anyone else.
I switched cold turkey to Dvorak and Vim at practically the same time (what can I say, I like pain :) I learned Vim mnemonically and have no problem using Vim on QWERTY. At the same time, I could have just as easily learned it "locationally" and been screwed. Only chiming in because I think it's interesting that the learning curves for location-vs-mnemonic seem approximately equal, but the long-term payoff of one is much greater. Neat asymmetry.