This compilation of podcasts by Skilldrick has some real good ones: http://skilldrick.co.uk/2011/08/podcasts-i-listen-to/
Especially, The Changelog and FLOSS weekly.
Also another small compilation from infoq: http://www.infoq.com/news/2011/09/archcasts
I especially enjoy On Architecture with Grady Booch: http://www.computer.org/portal/web/computingnow/onarchitectu...
Stack Overflow (now stackexchange, you can find the old episodes on itconversations), and techzing podcasts are packed with wit and humor. Listening to Joel, Justin and Jason, brightens any day.
I also subscribe to Compucast: http://computersciencepodcast.com/podcasts.html and Channel9: http://channel9.msdn.com/
Herding Code: http://herdingcode.com/ and radio free python: http://www.radiofreepython.com/ are on my "to listen" list.