Since the effects the study sees are related to menin levels in the hypothalamus specifically, I wonder, could targeted treatments of some kind still work? Maybe menin can be inhibited at tumor-related sites specifically or raised in the hypothalamus specifically, to separate the opposing effects?
It seems that simply increasing D-serine has some of the benefits of increased menin levels in the hypothalamus, but not all of them. It's downstream, metabolically.
From the Wikipedia page, its formation in neurons can be blocked. So maybe the preventative is to prevent and look for signs of blockage. I am totally out of my field here.
That's an interesting question! How long can modern science make a mice live? The oldest known mice lives in a zoo and had its 9th birthday last February. [0] I would have hoped for a mice in an aging research laboratory, but my quick search couldn't find cases with more than 5 years.
This has been written about for decades, Flowers for Algernon, Mrs. Frisby and the Rats of NIMH, and though it was by training instead of experimentation, Ratman's Notebooks.
https://www.targetedonc.com/view/menin-inhibitors-may-shape-...