The work may not be different. However, you have much more freedom in your choices and at the end of the day, your reward is much better for having to deal with boiler plates and life-sucking tasks.
I'm running a startup now and I've never felt like I've been wasting my life. I do, however, when I work for other people.
I crave the three elements of intrinsic motivation: Autonomy, Mastery, Purpose. More on that here: http://lateralaction.com/articles/dan-pink-rewards/