To my understanding you’re right (ie they don’t affect human cells) but there’s absolutely a chance the human immune system picks them up, but only really if they get in the blood stream. And really this is a secondary concern if that is the goal of treatment, because not doing it means the person probably dies. And due to the extreme sensitivity of a phage to a specific pathogen even having concerns about immune reactions in the future is likely to be a very minor concern given the alternative.
Most phage therapy I have seen/heard of is related to wound care and bacteria that is causing intractable antibiotic resistant infections (either superficial or potentially respiratory).
In these environments immune cells cant really effectively do their immune actions (because of the debris, and because a necessary function of effective immunity is effective circulation).
A good going blood borne infection being attacked by bacteriophages would be scary to treat someone through… intravascular bacteria being lysed causes a generalised inflammatory response that amongst other things is hyper coagulable
Most phage therapy I have seen/heard of is related to wound care and bacteria that is causing intractable antibiotic resistant infections (either superficial or potentially respiratory). In these environments immune cells cant really effectively do their immune actions (because of the debris, and because a necessary function of effective immunity is effective circulation).
A good going blood borne infection being attacked by bacteriophages would be scary to treat someone through… intravascular bacteria being lysed causes a generalised inflammatory response that amongst other things is hyper coagulable