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A secret language of cells? New cell computations uncovered (epfl.ch)
77 points by andrewfromx on Aug 8, 2022 | hide | past | favorite | 23 comments



I did an assignment on the Blue Brain Project once. It's an incredibly complex project with lofty ambitions.

One thing that blew my mind was how limited they were by modern storage technology. Storing high-fidelity neuronal cross-section images consumed more space than what was available at the time. Each scan was crazy massive, something like a petabyte or an exabyte.

To store the entire human brain in this fashion would consume more storage space than that which exists on Earth.


I've been curious if video codecs could be repurposed to store voxel data. Most approaches seem to use image stacks, but there's inherently going to be a lot of redundancy from slice to slice.

I'm sure a purpose-built format could be better with enough effort, but there's a lot of work put into video compression, so it seems like there might be a way to leverage that for some cheap improvements to 3D data storage. The storage solution that I've seen in practice has just been a folder of TIFs, so it seems like there's lots of room for improvement.


Can they trade off storage for compute by applying ML based compression JIT?


probably not cuz I'd imagine they want lossless compression (given as they don't understand the data well enough to do meaningfull (lossless) compression)


You can get very good lossless compression with ML models, it is just not very fast to decompress.



Was thinking of work like https://arxiv.org/pdf/1811.12817.pdf although the compression improvements vs classical methods are much more impressive for lossy compression


Are you referring to the work of Fabrice Bellard? I thought he only showed the proof of concept for text data, using language models, only?


I am referring to the work by Fabian Mentzer and related approaches, which covers both lossless and lossy compression.


Just saw this. Thanks!


I meant: meaningfull (lossy) compression


So essentially they found a meta-protocol like ICMP?


Disclaimer - you have to believe in the multiverse or multi dimensions for this comments but...

This is the transcript of the talk I heard that told me about Blue Brain:

"It's called the Blue Brain project in Switzerland. They have combined many different types of technologies and what they have done is they have essentially created a type of MRI that can scan the entire brain. All of the intricate structures of the brain itself and what they have discovered is that some of us and have in our brains fourth, fifth, sixth dimensional structures already. There are other people that have seven, eight, nine dimensional structures in their brain. You're a third density physicality and yet in your brain you have multiple dimensional structures!"

I always come back to the book https://en.wikipedia.org/wiki/Flatland and try and grok that hey, maybe dark matter we observe here in 3d is just stuff from these weird other directions a flatlander wouldn't understand.


What the what?

You don't have to believe in the multiverse because the dimensions they are referring to are not physical dimensions. They are mathematically orthogonal spaces upon which brain structures operate.


They are not referring to the same kind of physical (or even Euclidean) dimensions you are inferring. They are talking about connectivity and vectors.


It's interesting how physics lends itself to lay misunderstandings (like the parent comment) more than any other field of study, ie. chemistry.


I'll bet if this was an accurate quote, what was being said is technically correct but far less mind-blowing than as it was presented.


You are completely misunderstanding. Multiple topological dimensions, not spatial, and this isn't surprising at all.


Any chance you have any links to the talk you heard with the above transcript? Or any other links for further information?

Really interesting quote, would love to know more. Thank you.

Edit: I did some google-fu and found some interesting/relevant links:

https://www.sciencealert.com/science-discovers-human-brain-w...

https://www.wired.com/story/the-mind-boggling-math-that-mayb...


oh sure https://youtu.be/b4cGFVjtq-M?t=361 at the 6:00 mark. Fair warning everyone before you downvote, it's Alex Collier. Just take everything he's saying as satire if that helps.


Awesome, thanks! Appreciate you sharing the link despite the almost certain downvotes you'll get. Never heard of Alex Collier before.

If I may, as a thanks I'd pass along the author Samael Aun Weor which maybe you find some resonance with. Again to anyone else reading take everything he says as satire if that helps.


multiple dimensions != multiple universes


always been a many universes 1 dimension kind of guy.




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