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There are several methods, here is one:

http://www.marrow.org/Registry_Members/Donation/Donation_FAQ...

And here is another:

http://en.wikipedia.org/wiki/Apheresis

The second one is the more likely one to be used, the other is quite rare. In this case it seems it is 'only' the second (which is still quite bit more time consuming than a normal blood donation in duration).




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