The failure of the prior trial was suspected, and I believe it, due to a refractory response by overdosing the inner ear with too frequent administrations of the drug, and then testing for effect too soon. I bet even those candidates of the phase IIa trial though would, if checked on now, show some improvement.
Animal research has shown that natural cochlear hair cell regeneration and resultant hearing restoration is very real, we mammals just don't have the natural cellular signaling to redifferentiate those base cells - small molecule drugs like FX322 do exactly that. I am optimistic they'll eventually find the right dosing regimen to see reliable and optimal clinical effect, and it will be a seismic advance in medicine.
This is true of humans as well -- there are plenty of programs that get interesting and clear results in Phase 2 (the dose ranging phase: essentially "what dosage is most efficacious") that die in Phase 3 (roughly: "OK, how does that dose really work on a statistically significant population that also represents the demographics of the country"). These studies are so expensive that nobody goes into Phase 3 unless they believe Phase 2 pretty certainly demonstrated that the drug works, and well.
It's also hard to figure out just how the animal's hearing is improving (you can't simply ask). I'm sure they have some experiments, but growing the hairs back may be necessary but not sufficient. Look at all those Alzheimers programs aimed at removing the plaque that haven't demonstrated any value in the clinic. The plaque might not even be alzheimers itself -- it could merely be the body's response to some different underlying effect of the disease.
The choice of animal is very important, and the FDA cares a lot. Mice are popular because they are cheap. I worked on a program years ago that used guinea pigs because mice couldn't get the disease. We didn't use rats as the compound caused cancer in rats, and someone else had had their program derailed because the FDA required a separate analysis and study to demonstrate that the cancer was specific to rats and not other species (rats get lots of cancers). For our program the FDA required some studies in (non-guinea) pigs before they were willing to allow any human trials.
It's also hard to figure out just how the
animal's hearing is improving (you can't simply ask)
Oversimplification obviously, and "easy" is extreme relative to all the other hard parts involved but that part seems very doable
Essentially it's fractally complex.
There are various ways to measure these thing in animals and humans physiologically (ABRs, otoacoustic emissions, invasive and noninvasive electrophysiology), and with careful psychophysical experiments. None are perfect or comprehensive. Each method has its own strengths and weaknesses.
But it is indeed more complex than just testing a basic audibility threshold. The same issues come up with audigorams for hearing aid calibration and hearing in noise.
For that kind of thing, we're going to need real people who can communicate in detail.
"Rotating your eyeball" as a treatment for macular degeneration is a good example. Your brain needs a week or so to "reorient" even though the physical procedure is done in a couple hours.
Seems simpler than training a significant amount of them!
“How Loud Can Sound Physically Get?” - amazing breakdown of the subjective nature of loudness.
Basically, if we can regrow them, there’s a good chance of restoring hearing, provided the rest of the auditory system hasn’t atrophied too badly.
I hear a permanent and constant low-volume very high pitch "squeal" in my ears at all times,
I was never a big loud music listener, and I have always brought ear-plugs to loud events - and have had no big ear-rupturing moments (such as a gun firing close to my head without protection etc...
In the spirit of "there's a forum for everything," you can get help programming them yourself here:
But, I also enjoy being in silence.
Silence arrested by tinnitus.
I would enjoy a more meditative state... yet, tinnitus.
(Yes, I have tried "meditating it away")
Aside: I love you.
Manganese could also play a part because its the most abundant metal in hair samples which might translate to the hairs in the ear. However to get it there, you'll need to increase your cysteine intake, but we dont absorb it easily through the gut so we have to use N Acetyl Cysteine...
SO many chemical variables....
Acetaminophen doesn't have the same problem for me so I'm assuming it's not just that I'm clenching my jaw without noticing.
The only tip I can give you is to always have some kind of background sound that you can focus on rather than the buzzing in your own head.
Also, avoid earplugs and headphones, they just create a wierd feedback loop.
A couple of the things I used to tell myself when it troubled me more than it does now:
- There's nothing you can do about this, so just forget about it.
- We all accumulate damage as we age. None of us are going into the grave in prime condition and if we do, that's a mark of a life not well-lived.
- The fact I can hear this noise means I'm alive: "I hear ringing, therefore I am".
These may not be helpful to you, so invent your own!
The other thing I would recommend is getting a hearing test. If it turns out you have hearing loss, then treatment for that (e.g. hearing aids) may reduce your tinnitus (one theory is that tinnitus is caused by your brain "turning up the gain" on your "audio inputs", so that when you have a hearing aid, your brain no longer needs to do that, and your tinnitus diminishes).
If it turns out you don't have hearing loss, then you can reassure yourself that your tinnitus is not a sign of any damage. I had always assumed my tinnitus was the result of damage due to a lot of music events but it turns out I have excellent hearing, which helps me ignore my tinnitus, because I no longer view it as proof that I hurt myself.
You may also notice that certain things make your tinnitus worse. For instance, if I have a few drinks, mine gets noticeably louder. But because I know the alcohol will wear off, I just ignore it because it's temporary.
It depends. My friend had a bad tinitus for years. He thought it was from clubbing and the jet noise in the military.
He just has bad hearing and with his hearing aids, the tinitus is gone.
I personally think this is great advice. I just imagine that the noise is the firing of my synapses.
With that said, my advice to you is, don’t do that. ;) Maybe you have it, maybe you don’t, so probably best to just ignore it, because it’s not a problem unless you start paying attention to it.
Interestingly, having this conversation on HN has made mine more noticeable, so, I better move on too!
You might want to experiment with changing your diet, drinking more water, etc.
I do eat a lot of sodium, but here is an interesting anecdote:
A friend's husband had Lyme Disease - and had very bad veritgo from it which was exacerbated by a high sodium intake (I assume the ear works on the sodium potassium pump in some manner?)
but she used to have to make a very careful diet for him so as to remove sodium as much as possible, which would prevent his vertigo.
"Where an inflammatory component is suspected in bilateral Ménière’s disease, short courses of systemic glucocorticoids may be appropriate. It recently has been shown that glucocorticoids not only influence inflammatory process in Ménière’s disease, but also alter fluid dynamics via an interaction with the sodium pumps in the semicircular canals (Ponduglula et al 2004). Intra-tympanic application of corticosteroids appears to have only temporary effects (Dodson 2004) and is probably not recommended"
The trials preceding the Phase IIa results were all extremely promising, and even the Phase IIa one showed statistically significant effect on a sound discrimination, which many long time hearing sufferers can tell you is even more frustrating a problem than the inability to perceive sound.
Biomedical research stocks are inherently risky. I could be deluding myself, but my lay reading of the research, and as someone who has suffered from tinnitus for a long time brought on my noise overexposure, I think there is a very promising shot at this drug. Maybe FREQ will not be the ones to realize it and some other company will take the patent into real life clinical medicine, and FREQ is certainly not the ONLY company pursuing this angle. But their successes so far have kept me holding the stock, and I keep buying more.
Interesting approach, I'd love to see it work. But given the mixed results plus the class action lawsuits that still seem unsettled (at least I didn't find any news), this doesn't really seem investable to me. Biotech startups are risky enough even without such problems.
What other companies are working on this problem?
My hearing loss is mostly on the high end (10-12K and above) and impedes my ability to hear speech in noisy environments. More troubling has been the inability to enjoy music/sound in those upper ranges, resulting in the music lacking a certain sparkle and brilliance.
I hope this therapy regenerates hair cells across the entire spectrum.
Amplification doesn't fix everything. My hearing loss is complex, a mix of conduction problems in the middle ear and something neurological as well. I can hear very high and very low frequencies surprisingly well. There's a big bite out of the main speech band, though.
I find that speech, with background noise, that goes through a mediocre microphone, 200 - 3000 Hz pass filter, and then a digital compression codec, and then through a loudspeaker -- no matter how loud -- can sometimes be nearly unintelligible to me. It's loud enough. But I can't figure out which sound that's supposed to be. It's just too distorted.
I take my hearing aids out to listen to music, most of the time. Despite usually being able to better hear the melody and lyrics with the hearing aids in. Because I know the sparkle you speak of, and it's wrecked by all but the very best-quality electronic amplification. Some people think it's odd that I'm finnicky about quality speakers, etc. when I'm half deaf. But every decibel of SNR counts when I lose most of it in my head.
(And I too hope one day they can fix that for both of us.)
What I probably need is a DAC for my sound system. The music streaming services like Apple don’t provide an adequate way to equalize the audio and balance to compensate for my hearing loss.
Edit: I keep hoping that Apple will do a better job here with their next release of AirPods Pro. One of the problems with Apple Music is they set the max volume too low. I can sort of understand the desire to help people protect their hearing, but their max level is less than IRL, and there is no way to bypass that setting.
Tidal is better. And there are plenty of YouTube channels I listen to at half volume, so it’s not the Apple hardware causing the problem.
There's still plenty of good music out there.
I also find that my hearing aids aren't great for music due to how much they change timbre from boosting the high end, so I use regular ear buds instead.
I mentioned different eq curves down thread. I don't have a lot of technical data at hand, but older radios from the vacuum tube era where they had response over 10 khz.
A good one, play that a respectable volume in a room, sounds pretty great!
What I'm kind of hinting at here is there maybe Equalization curves that can satisfy our need for that bright open sense that is missing when the higher frequencies are also missing.
Maybe the 4khz range is what was emphasized on older audio gear. I am thinking about the great overall impact that gear delivered is intriguing to me.
Another thought I had is how filters differ from an organic lack of response. Filtering wide band audio introduces artifacts. Those can be heard on AM every day in the US in the stations using brick wall type 5Khz filters.
A wideband signal run through something with low response is different!
And the cutoff matters.
No matter what the gear, a 5khz cutoff is crappy. 8khz can be good, and 10 can be hard for many to tell given good gear and quality source audio.
Once, I was able to listen to a great jazz recording on a older tube stereo. 50's era gear.
Playing vinyl on it was a terrible experience for both the listener and the vinyl. A recording done on tape was kind of amazing! The device was mone, pretty sure was a Zenith, and it had a cool baffle system on the speaker. One "tuned it for the room" by pulling a knob in and out. That shaped the low and mid range.
Was better than I would expect for that overall bandwidth.
I'm an audio engineer, not an audiologist, so I'm just shooting from the hip here as it's something I've been curious about in case I develop a similar issue as I age.
Look at https://positive-feedback.com/Issue66/hearing.htm if you want to hack something together that will work better and not damage your hearing.
But, I’m actually quite sensitive to loud noises!
What I need is equalization and compression, so I can hear the soft noises. I don’t need much, if any, overall gain.
Why can’t Apple provide that, they have all the necessary technology at hand?
I always find The Sound of Music as reproduced on older narrow band with am radios and phonographs interesting. A lot of that gear doesn't really produce anything over 10 khz.
But, where they emphasized frequencies in the spectrum is different from Modern equipment, which basically is shooting for flat response.
My grandfather's old radio, when played in a room have a comfortable volume, sounds really good. It's present. And even when I use the little transmitter to send it an idealized signal, it had a roll off starting around 8khz, the absolute high-end was maybe 12khz.
I never took the time to analyze it in detail, and kind of wish I had. The usual 62-100 hurts emphasis, like what you'll find on your typical loudness button on a 70's or 80's stereo was there. But it also shaped the sound in 3 to 8khz range.
The end result was a very natural sound the didn't overpower, felt like it should be there in the room with all the other sounds.
Wish I could say more but I'm not where I have any detail information. I can say the enjoyment of the music is different, and fulfilling. It's not bright, like those higher frequencies bring to the overall feel of the program being produced.
Robust, full, seem descriptive... clear is another one. Often, when I hear high bandwidth audio, through limited devices, it seems muddy, unclear, not precise. Those older radios are not like that. Well, the better ones anyway.
In any case, the eq is different, and that impacts our perception related to the overall feel of the sound.
Sorry for the typos. I'm doing this with the voice dictation. I may actually go back and revisit this myself. As I age up I'm getting be expected, natural roll off most all of us get in our later years.
You go back far enough, and the gear starts to roll off about 10 khz, yet if you listen to a modern signal through it, it sounds good. That's what I'm getting at.
Ah, me too, but no sound at all. A specialist told me it was caused by a virus, but I never looked into which one, or asked for more info.. There was no treatment, except cochlear implant, which didn't sound too great. Hopefully it doesn't happen in the other ear also!
I'm having trouble finding information on it, because there's a lot more money in orthodontics than palatal expansion:
Right now I'm wearing Invisalign but have a small 1/2 tooth gap where the new bone has formed and am having trouble finding an orthodontist that will move molars forward to catch up. It's like asking someone who just dug a giant hole to fill it in again. It may require a temporary anchorage devices (TAD) or lever arm to move the teeth without tipping them.
The programmer in me senses a code smell here where the orthodontics profession maybe shouldn't endorse practices it can't undo. But all I can really do is spread the word and encourage anyone considering braces to get a second opinion, especially for children. They may just need to wear a retainer for a year or two and learn good tongue posture habits, especially while they're still growing.
To shed some light on what's going on here, I feel that the Herbst appliance is the best up through the late teenage years, but notice how info on it is behind a kind of industry blacklist:
As of this writing on Easter Sunday, April 17, 2022, the above Wikipedia entry is blank. That's what I mean about the programmer in me smelling so many code smells here that something doesn't add up.
IMHO what's going on is that the practice of orthodontics was created before things like dental implants went mainstream or were even thought feasible. So today, rather than headgear, it's better to just install the temporary anchorage devices (TAD) that I mentioned, then use a more consistently-applied force from bands or screws to move any tooth exactly where it needs to go. I feel that orthodontists who are reluctant to do this haven't kept up with the literature, or are afraid to do work outside of the niche they're comfortable in, indicating that their professional development work might have fallen behind.
In short, get a second opinion and/or find a better orthodontist.
But it sounds like you're on a good track. Just remember that you're moving roots (not teeth), so bigger teeth take longer because they have more. Also you're moving a lot of teeth, so each one has to move a millimeter, then the next, and so on. So molars may take an order of magnitude longer to move than smaller teeth.
I'll likely need one of these techniques to close my gaps, even though they're from new bone growth from the ALF instead of lost teeth:
tangentially I also have tinnitus so now I'm wondering if it's related.
Quality of sleep is through the roof, I'd forgotten what good sleep is like. If I miss a night of sleep with it (e.g, I travel and forgot to bring it with me) I absolutely feel it the next day.
Tinnitus-wise, I noticed that it got worse at first but then settled and is actually more in the background than it used to be. FWIW, I've had tinnitus for as long as I can remember, so I'd consider myself ~90% habituated to it - it doesn't bother me outside of any concern of it getting worse. I think this has made it easier for me to objectively judge whether something is helping or not - if my tinnitus is never cured, but never gets worse, I'll be fine.
https://vivos.com is what my Ortho got me on. I can't speak to others, but this has worked well for me so far.
Anecdotaly, I've found myself getting a phantom tone in the 15khz range (sounds just like a flyback) when in a quiet house. This could be entitely placebo effect, but I've gotten some relief by doing a bad emulation of active noise cancelling headphones, namely
playing a quiet 15khz (ish) tone through my bone conduction headphones. It's not perfect by any means, but often the very act of trying to tune my tone generator to the right frequency can be enough to stop it annoying me (it becomes less noticeable).
Im curious if anyone else has tried similar?
Maybe it’s easier for us to accept certain things when we are younger. if it happened today I probably would be more anxious about it. It also helps that mine hasn’t gotten worse - I noticed it, took corrective action, and continue to be mindful about it thru today
I don't get my medical advice based off what some guy who starred in a low-budget sci-fi space soap for three seasons thinks.
Oh I don't have trouble growing hair in my ears. I have trouble hearing.
My mother has poor hearing and she refuses to get a hearing aid mainly due to cost. They are ~$4K per ear she doesn't have the money but to her an elderly person she imagines it as $40K/ear. I also fear dementia has already begun for her. For me I have tinnitus so this drug would also be welcome.
Another interesting drug is Vuity for nearsightedness. Between hearing and sight it will be amazing if such drugs work and were available before my mother or I or anyone dies of old age.
Heck, if she gets an earmold, I can give her my old Oticon Chili. I bet there are other avenues to procure a cheap one.
I also know my Mom and how to her $10 is like $100 so hearing aids even $1,000 to her would seem astronomical in price. She'd retort, "I'm fine without them".
It's been a decades long battle someday she may give in.
I had a Bose Hearphone, but it broke. It worked quite well - I think about as well as the high priced aids. Sadly, Bose discontinued it (why??) and I can't replace it. With four mics, it was able to cancel sounds from behind you. You only really heard the person you were facing.
Edit: I notice their dual-microphone Volts are selling for $300 a pair, also. I haven't tried them - but dual mic is what you need in noisy environments. Might be a really good deal.
If you had been subjected to a life-threatening high body temperature (106.5+ F, spinal meningitis), your cochlears would make for a poor candidate in benefitting from most form of treatment of cilia hair regrowth.
The problem is the fibrocyte nerve pathways (the ones embedded in the wall of the cochlear spiral) are basically heated to death through bursting/disintegration of its Mylar sheathings of its nerve cells in the cochlear pathway.
Although, not much research is done with regard to the temperature level in various part of the body notably inside the skull region during such an infection, it is arguable that cochlear is located in the hottest zone of the body given the locality of eustachian tube, inner ear and throat region being a harbor of Infectionous activity.
Not an expert here but a pretty serious consumer-based researcher of CI.
Before I had this I assumed wrongly that hearing loss could always be fixed by making sound louder. (It doesn't, just sounds like a voice disguiser or someone on Helium talking through a bad speaker.)
This looks promising.
I have a severe sensorineural loss in both ears and wears hearing aids with a lot of success. My loss was the result of some unknown illness when I was younger - a loss resulting from illness or drug reaction tend to present randomly across the frequencies, whereas an age-related loss is almost always a "ski slope" loss, which means the high frequencies are mostly lost and the lowers are mostly fine.
Your experience is very common with new hearing aid users. The aids are able to increase volume at specific frequencies as defined by your hearing test(s) and the other features of the aid, e.g. noise reduction and compression are able to give a great quality of sound. The problem is usually in the person's ability to comprehend these new sounds, i.e. their brain, not their ears. A person with a hearing loss typically takes seven years to try out hearing aids, in those years their brain has got used to not hearing certain frequencies and sounds altogether and it can take time and training to get that ability back.
There is not really a great set of tools for brain training part of the hearing problem at the moment, in my opinion its badly overlooked by the hearing industry.
This is a very interesting book: https://www.amazon.co.uk/gp/product/0262045869
An audiologist should be able to tune your hearing aids to amplify only those frequencies that need amplification.
(Although my understanding is that this is fairly new, and may not be available around the world)
But the serious problem with hearing loss is the "bandwidth", meaning the damaged cells send less information to the brain even if attenuation is compensated by hearing aid, leading to bad recognition of sounds and speech.
An audiologist will typically test someone, see that they need amplications across the range but send them away with a much lower amplification for a weeks to get used to things. Then bring the volume up as time goes by.
People amy also need to get used to the aid's noise reduction algorithms as they can seem unatural at first and is a nightmare for anyone who used to wear an old analog hearing aid with no noise reduction.
So, yeah, hearing aids are rarely plug-and-play from day one - the user needs time to adjust.
We should be cautious about suggesting unproven remedies.
What I find interesting though, is that I distinctly remember as a young kid living in the countryside that I found it impossible to hear absolute silence. I distinctly remember sitting on a bale of hay on a bright summer's day with not even a breeze and the quieter I perceived things, the louder a 'TV-like wheeee' noise (as I knew it at the time) became to fill the void. I always thought I had a special talent for being able to tell when a TV (CRT) was on anywhere in the hosue, as I could hear its high pitched whirr.
Now as an occasional sufferer of fairly bad tinnitus, I often wonder what any of the above means, as there's surely something in it.
Only coping strategy I have is to not fixate on it, whereupon it dies down. That's tricky those times it crops up at nighttime and I'm staring at the ceiling at 4am trying desperately to get back to sleep... .
We go four week long Outdoor Adventures, where nothing works except for AM radio late at night.
After a few days, hearing very significantly improves. On the last trip we took a Macbook, and watch the movie about 4 days in, and we're shocked at just how great that laptop sounded! It seems very loud and amazing, where in an ordinary City environment it's just normal acceptable sound.
Any of you that get a chance to try this really should, it's dramatic. And it makes me really appreciate the audio engineering that went into those devices. A lot of that engineering won't ever be heard by people for in urban environments, but it is there, the work was done, and the results are pretty fantastic.
I never got the 'nee-naw nee-naws' from DMT or Ayahuasca when I did such things, but I absolutely did when going deep on Nitrous Oxide. DMT was always entirely (and oh my gosh so absolutely) visual for me.
I've always asked myself - how could I get this if I always had good hearing? Is this even anyone's fault? How could a child have tinnitus when it had no real chance to get it?
This entire post+comments has me almost in tears - my tinnitus gets unbearable e.g. when I'm stressed, panicking or overstimulated. It helps to know someone shares my pain, even if this treatment won't become available in my lifetime. I'm used to having stuff playing in the background anyway, it's just the times when I can't drown it out when it's the worst.
PS: BTW, something interesting happened to me recently: I recently visited a retro game museum while on vacation. Being obviously filled with old TVs, the noise was nigh-insufferable for me, but I pushed through because retro games is my thing. We spent ~1hr there and after we left, I felt like my own TV noise was somehow better for the day. Weird.
Some of those television sets were super loud!
Some of the minor tinnitus I have, as in those frequency ranges. And it doesn't really bother me, because I grew up with CRTs.
I have never encountered someone else that was able to hear whether a tv was on or not. At what distance could you do that?
A video signal synchronized up has a very distinct profile, and people who can hear about 15 khz can hear the sync signals modulating the higher frequency component.
I could at one point, adjust horizontal and vertical hold to a stable signal eyes closed.
Some sets were very loud, and I could hear them rooms away. Walking The Halls in my primary school, I could walk by the classrooms and say they have a TV on oh, and nail it a hundred percent every time.
I don't recall hearing the same noise from fridges though!
Never really considered the high-frequency experience a problem; it's just always been part of my sensory experience.
And at turning off the aids, if the old bat starts chattering excessively.
Also found there's FX-345: https://www.youtube.com/watch?v=bV4js_9GUwc
I grant you, some people who use "trigger warnings" would have added one before talking about suicide rates. I however do not use them outside mental health forums and such.
If you have severe tinnitus, look at getting hearing aids -- they fill back the affected frequencies so your brain doesn't crank up the gain and fill them with the phantom sound. Or look at Tinnitus Retraining Therapy. But most people do habituate to it. What you read online on the tinnitus forums and so forth has selection bias. People post on the forums how terrible things are right after they develop tinnitus, but after they habituate to it, they don't post as much about that.
I recently caught the covid virus. The symptoms were bad but far from what annoyed me the most from it. The worst is how since I have had it, my tinnitus is back to the forefront of my life and louder than ever. Many people who have managed to ignore their tinnitus will have it come back when they are exhausted, tired, sick, stressed, etc.
Being dismissive and saying you can learn to ignore it is not really helpful, this is true of most conditions. This article however offers a tangible cure.
Not to be dismissive either but the ringing from hearing music that is too loud is the mildest case most commone case of tinnitus that exists and will often simply reduce by a large margin on its own. Chronic tinnitus is defined as a tinnitus that lasts more than six months.
In my case, it's at the level of a lawnmower behind a thin wall when at it's worst and mosquito near the ear when at it's mildest. In some other cases, it's car engine and even jet engine level. To me your message (while probably not on purpose) comes across like someone with an amputated finger talking to someone with two amputated legs about how you can learn to live with it (especially with the talk about selection bias, which is useful when looking at trends but not when talking to individuals). Yes you can control it and yes it's the same medical condition. But it's not the same beast.
I find it curious since I've had tinnitus since I was very young and it isn't life wrecking - but maybe that's because it is just part of my default life experience.
And yes, I understand that suffering is relative and that there are worse things than Meniere’s disease, thank you.
Having a lawnmower in my head at all time is not the end of the world. But it's certainly exhausting and sometimes disabilitating.
It's meaningless to compare health conditions. What's the worst between something that kills you, something that paralyzes you, something that gives you constant pain and something that triggers constant fear in you?
All of them. All of them are the worst to people who suffers from them.
Tinnitus is brought up in the article, this is why people are talking about it. Not because it's a condition that is worst than others.
Reading about a possible cure is one of the are form of hope someone with tinnitus will ever have.
I’ve been afflicted with tinnitus after a mild covid case in January and now that I’m looking it seems like this is a growing problem. So many comments here about tinnitus.
Not the usual steady tone tinnitus either.. almost like a loose wire sending a very specific frequency in one ear.
Spontaneously resolved after 4 months or so, no recurrence with a second round of covid.
Texas Roadhouse CEO developed severe tinnitus after having COVID and took his own life because of it 
I don't feel pain or ringing but those sounds definitely irritate me in a disproportionate way.
Does that sound familiar to anyone?
(I have a specialist appointment in the way but I'm quite anxious in the meantime)
Do people realize that they essentially function as hype-generation outlets and are not intended to provide an objective and unbiased assessment of the research?
And really, the original press releases tend to be quite a bit better than the 'science blog' articles that regurgitate them, coming from a university url isn't a bad thing.
I check all the boxes for tinnitus behavior (loud blasting music hours a day for years) but only have mild tinnitus at worst. I do however have hidden hearing loss, where I absolutely cannot understand what people are saying if there is too much ambient noise. Bars are hopeless situations for conversation, even a fan on in a room can make conversing difficult. It would be nice to revert this (and secretly go back to occasionally blasting music so loud your organs feel it).
However, hearing loss has already been successfully cured before decades ago. I remember reading back in the 80s that it was only 10 years away.
It actually worked.. only problem is, the dosage required was toxic for humans.
So when they say it is years away, take it literally and assume that might be forever.
If you have hearing loss that can be treated by other therapies today, do not wait for tomorrow, because tomorrow may not come.
Happy to share my story and some resources - my email's in the profile. Best of luck to you and your family, and I feel for you.
Personally I am concerned that a CI would not improve my quality of life and may even make it worse. My understanding is that the hearing from a cochlear implant is not the same as "normal" hearing so I worry it may effect my current experience in a negative way.
Speak to the doctor but I would personally be a bit cautious about it, especially if your daughter is not at an age where she can properly communicate her experience of hearing with you.
If you ever encounter a person who instead of making eye contact seems to be looking just over your shoulder, it could be you are about to be attacked or it could be someone like me who needs to turn their one good ear towards you slightly in order to hear our conversation. :)
Personally, I only notice it in very loud situations in which someone is speaking to me on my deaf side; otherwise the sound bounces around and reaches my working ear anyway. I don't feel "disabled" in any way. In fact I rarely think about it. I've been given a hearing aid, but I don't bother with it, frankly I just don't need it. The body is quite amazing at adapting.
One weird instance happened about 25 years ago. I suffered a severe blow to the back of my head. My hearing in my bad ear actually came back for a while but it was like listening to a poorly tuned radio. Proper volume but full of static. After a week or so, my hearing returned back to its normal deficient state. No idea what exactly happened or why.
Looking forward to the progress in this.
Does this mean this treatment works only for these conditions, and not common aging-related loss?
The mechanism should work if there are viable progenitor cells present (so I would expect it to be of some use in most cases of hearing loss), but they may not be able to develop this drug into a reliable treatment.
His hearing has now declined to the point where he needs a cochlear implant, and I worry that if we do that and a treatment is eventually developed, he might not benefit from it. However, I think it would be foolish to wait. Gene therapy seems like the only hope, and I don't think there have been great developments in that area.