The RTA is very good for getting downtown or to University Circle (and possible Ohio City). Unfortunately the jobs have all moved to around 271/480. I did the 48->7 reverse commuting from Shaker Sq. to Highland Heights when my car was in the shop last year. Let me tell you, that sucked. Nearly an hour and half vs. 30 min driving. And there's only 1 bus the entire day that took the special route I needed.
I live in Hudson, so public transit will never help me much. I used to live in University Heights, a suburb which grew up after the RTA lines were laid out. Ironically, I have been working in Chicago during the week for the past few months and have been getting by a combination of public transit and taxis. $150/mo parking in the condo complex where I am renting coupled with $20/day-ish downtown parking makes a $8 taxi ride a bargain (not to mention the $2.25 bus fare). It also helps that iGoCars (a non-profit zip car competitor) has stationed a car right outside my building.