If you're looking for Lisp-like meta-programming, I'm pretty sure you don't want Node. It may be easier to grok, but that's because it's much closer to Ruby and Python than it is to lisp. The interesting thing about Node is its event-driven structure.
For that matter, you might not want Clojure to be your first lisp experience. Have you considered Racket, the scheme dialect? It seems to have lots of useful libraries, in addition to being, I don't know if "cleaner" is the right word, but something like that. A bit more traditional, maybe simpler.
I don't have that much experience with lisp or Node. If someone with more experience can correct my impressions, I would be grateful.
As someone who's used Common Lisp, Scheme and Clojure; out of that bunch I would highly recommend Clojure for a beginner.
1. Easier to setup
(with a single script from https://github.com/technomancy/leiningen)
2. Benefits of a lisp-1, with nicer syntax (fewer confusing parens)
3. Easier to get started with Emacs + swank-clojure + lein
4. Wealth of Java libraries
1. Can't think of any, unless you want Interface Builder and similar, or are desperate to program using call/cc or are in any of the above ways a non-beginner. drscheme is a nice counterpoint though, in that the learning enviroment could include a bit more hand-holding.
IMHO for those coming from ruby/python etc. Clojure is a huge win. With square brackets for function-args, if you turn off or dim parens (emacs has several options such as rainbow-parens) the source looks very much like python.
And with M-q and friends and sexp editing, it behaves better.