Yeah, I just listened to the entire podcast on the subject, and this whole "JS as assembly" is just dumb. The guy seems utterly mixed up about what JS, assembly, and IL represent.
His entire premise is based on the idea that you can convert one language into another, and therefore the target language is equivalent to assembly. That's ludicrous. I believe Facebook converts PHP into C or C++, therefore C/C++ is the new assembly. What?
The guy should just stick to talking about techniques for using cleaner languages and converting them into JS. Instead, a bunch of link-bate BS was poorly conceived and thrown in.