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The risky bat-virus engineering that links America to Wuhan (technologyreview.com)
274 points by apsec112 on July 2, 2021 | hide | past | favorite | 255 comments



All: please don't post generic comments [1], and definitely not generic flamebait comments [2], in threads like this. Those are repetitive, tedious, and therefore off topic (https://news.ycombinator.com/newsguidelines.html). Edit: we don't want to just repeat the same argument over and over, because there's no curiosity in that [5], and because it usually turns nasty [6].

The value of an article (and thread) on a major ongoing topic, such as this one, is in the specifics of what the article discusses—in other words, the diff relative to previous articles and threads [3]. If there aren't any new specifics, then the article itself would count as off topic [4], but in this case there do seem to be.

[1] https://hn.algolia.com/?dateRange=all&page=0&prefix=true&sor...

[2] https://hn.algolia.com/?dateRange=all&page=0&prefix=true&sor...

[3] https://hn.algolia.com/?dateRange=all&page=0&prefix=false&so...

[4] https://hn.algolia.com/?dateRange=all&page=0&prefix=false&so...

[5] https://hn.algolia.com/?dateRange=all&page=0&prefix=false&so...

[6] https://hn.algolia.com/?dateRange=all&page=0&prefix=true&sor...


The quest to come up with a narrative for why Covid happened reminds me of the reporting when Katrina hit New Orleans. The city's vulnerability was known beforehand [0] but the inevitable disaster was greeted with shock, confusion, and a search for peripheral explanations. In the case of the pandemic, our vulnerability to zoonotic viruses and other diseases was also well-known; e.g. [1] was published in 1995. But again the reporting, as it seems to me anyway, focuses on the particular circumstances of the disaster rather than our fundamental vulnerability. There is a plentiful supply of unknown microorganisms to fuel the next global health crisis, and we need to expect and prepare for it so that next time we can prevail without great struggle.

[0] https://www.pbs.org/wgbh/nova/article/predicting-katrina/

[1] https://www.goodreads.com/book/show/46722.The_Coming_Plague


As an aside the Katrina stuff was odd - I was in Ireland watching cable (CNN I think) and for 48 hrs or so they'd been going on about New Orleans was likely to flood, on repeat, at least hourly, so I thought I'd get the popcorn and watch (I didn't think it'd be that bad). Then it flooded. Then Bush popped up saying no one could have predicted it would flood. Strange - guess he didn't have CNN.

The lab leak reporting is also odd. When it first happened my initial thought was natural, then when it came out it was next to a lab doing gain of function type experiments on coronaviruses and hundreds of miles from the bats I thought ah likely a lab screw up. This was around feb 2020 that the info came out.

But then the press has done a year of lab leaks are mad, possibly racist, conspiracy theories and then a couple of months of it's likely a lab leak, all based on basically the same facts. Also odd.


For comparison, SARS was first identified here (https://en.wikipedia.org/wiki/Foshan) and fifteen years later a tentative source in wild was finally found here (https://en.wikipedia.org/wiki/Xiyang_Yi_Ethnic_Township). The distance between the two places is around 1100 km. Was that a lab leak as well? And pray tell, from which lab did it escape?


I think part of the quest is about deciding if gain-of-function research is safe and should be allowed in the future.

If it happens to be the root cause, no doubt there will be a huge change in how it is carried out, if not outright banned.

If it is proven to not be the cause, it will be easier to argue that it can be safe.


To be honest, I never really bought into the lab escape theory. Still really don't, with all the investigations going on I am willing to consider it as an alternative. Thing is, I have yet to see a timeline, starting with the earliest cases elsewhere, and a summary of the genetic research into COVID-19. Without having the time, and knowledge, to deep dive into the studies I jave to rely on news reports. And those, IMHO, are more about creating clicks than really informing people.

Curious to see what comes of that so. Not that it would change a lot in term of fighting the pandemic, we have working vaccines by now. The narrative will change a lot, so. And with all the mask clusterfuck still going on, I don't think the narrative will be good.


Interesting - I've been thinking it's the obvious case for a year now since I first read about it. Just too many coincidences and a lack of evidence for any of the alternatives to disprove the lab hypothesis has come up since.


> a lack of evidence for any of the alternatives to disprove the lab hypothesis

I'm not sure that "disprove my wild hypothesis" is how proving things works.


When nothing has a smoking gun, and you've got volumes more circumstantial evidence for one thing than another, it does not serve one well to stick their head in the sand and not move forward under the assumption both can be right.

When you run into massive resistance to doing so, it only points one in the direction that there may be more to be uncovered in one direction than another.

>Come on in guys, let's compare notes research wise!

Would have done volumes more to defuse suspicions than nothing but stonewalling and saber rattling.


Smoking gun in the original SARS took 15 years to find and it was found in bats in a cave 1100 km away from the first outbreak. What exactly are you expecting two years into this outbreak?

The "circumstantial evidence" is that pretty much all recent new infectious diseases in humans were traced to animals in the wild, or alternatively, sometimes not traced anywhere at all (Hepatitis C, anyone?). "Yes, but this one is special!", conspiracy theorists swear. Sure, Jan.


Eh, I wouldn’t be so quick to dismiss it.

One analogy I heard recently is that lots of people get covered in paint worldwide, but if you see 10 people covered in paint right next to the dulux paint factory, you should probably consider the likelihood it came from there, even if the paint factory denies it.

Let’s not forget that we are talking about the outbreak being right next to a lab which was known to have inadequate safety precautions which was trying to make bat coronaviruses jump species.

We are also talking about a strain that, if it began in a lab with inadequate safety standards, could have very easily escaped due to its high infectiousness and low detectability due to asymptomatic carriers.

Might we find it in a cave? Of course. Might we find it started in WIV? Of course.

The only people I personally think are silly are people that outright dismiss either option.


It's hardly unprecedented, look how many related viruses have escaped from research sites before in China, including SARS.

https://en.wikipedia.org/wiki/List_of_laboratory_biosecurity...


https://project-evidence.github.io/

https://archive.is/tpxg1 (Nicholas Wade's excellent medium post, one hundred percent worth the read, Possibly duped in the Bulletin of atomic scientists shtick floating around right now.)

>https://archive.is/ONgMa Yuri Deigin's excellent write-up

I expect in the absence of a smoking gun, that people weigh the relative preponderance of evidence and do reasonable things. The preponderance of evidence clearly tilts in one direction over another, but the people closest to the subject matter at hand have rather tangible conflicts of interest in controls implemented if the story tilts against their preferred zoonotic spillover which conveniently absolves any human agency of responsibility.

Mother Nature throws us a curve ball every once in a while to keep us on our toes. Other humans do so with a probability approaching 1, and I see evidence of all the tools and expertise necessary to have constructed the ball from scratch, measure that, in fact, this is the ball that will curve the way we expect it to, and through it all I've seen the most grossly blatant active perception management of facts and science by media and government alike that I've ever had the misfortune to witness. I've had my eye on the community and volunteer collated pools of evidence and have actually been running down references and anomalies and watching things evolve since this first entered the public eye as rumors of a mysterious illness back in 2019, and even before that, when my interest was piqued by some seriously questionable research papers getting published every few years over the past decade in terms of "You were so busy wondering if you could, you never stopped to ponder if you should." I've done my level best to ensure that I fully delve into the subject area enough to actually form a reasonable stab at a fact based opinion, including integrating new info as it became available.

It's not my burden to prove zoonotic. I welcome those looking for it to find us the smoking gun we need to put lab-leak to bed. I also welcome lab-leak to do the same for zoonotic. Until then, I propose doing something about all the smoke in the room as it's a little odd how everyone just seems to have handwaved the possibility there is a fire making it.

In the grand scheme of things, the only people with anything more to lose are the ones most vocally advocating everyone not look behind the curtain, or actively making it more difficult to and that everyone else just doesn't understand.

I understand perfectly. China has sovereignty issues to deal with. They have a bunch of other red marks going on in terms of baggage foreign and domestic policy-wise and don't want to make it any easier for another one to get dropped on their doorstep. That's fine. I don't care half so much at this point.

I care that we've got a bunch of institutions at each other's throat trying to fist feed advantageous narratives and lies through omission instead of everybody putting all their cards on the damn table, and we're doing some of the most dangerous damn research I can conceive of in ways where it convenience of the researcher even comes into the picture. G-o-F on Viruses are the biological equivalent of bloody "let's make grey goo" in nanotech.

But I get it. That's life. It's absurd. It will continue to be absurd. People have to look at other people in the most uncaring or warped way to think helping anything along it's evolutionary path to human infectiveness is a good, viable research topic to take place anywhere near other people. I don't even begrudge Baric or Zengli Shi. I begrudge the complete lack of foresight and institutional self-reflection that surrounded this type of research even having all the necessary tools collected in one place without audit controls just in case this sort of thing ever came into question to keep it from blowing up in everyone's faces. assuming the risk it presents would ever be reasonably mitigated is the very definition of foolishness and blindness to human fallibility.


The circumstantial evidence is that the initial outbreak was concentrated in a wildlife market in Wuhan, on the opposite side of the city from the lab. The SARS outbreak began in a nearly identical way, in a wildlife market in a large city, 1000 km away from where the bats live.

There's no evidence that the lab had this virus previously, and there's actually good evidence that they didn't have it (they publish on the viruses they discover, and they never published this virus).


> with all the investigations going on

There are no investigations going on. What the F are you talking about? The communist dictatorship is not letting in any investigators. They have every incentive to prevent any investigation, and they do so.


The vulnerability in this analogy is scientists working with viruses in BSL-2 conditions.

I would argue this was not a widely known fact.

It's difficult to prepare for the next disaster if you're not willing to explore the previous one.


There’s going to be a ton of comments on the lab security aspects, but there are two other big takeaways from this article:

1) Researchers easily found multiple naturally occurring coronaviruses that seemed likely to be able to jump into humans. In fact that is why they were so eager to conduct that lab research: the natural threat seemed imminent.

2) The sequence of COVID-19 does not yet resemble any of the sequences associated with the lab research that was being conducted.


> 2) The sequence of COVID-19 does not yet resemble any of the sequences associated with the lab research that was being conducted.

This doesn't discount the possibility of a lab leak if you take into account that some sequences appear to have been deleted[1].

We shouldn't make assumptions based on lack of evidence if that evidence was tampered with. And given China's history of deliberately concealing facts to save face, this raises far more questions than it answers. We need a serious and trustworthy investigation into what happened that puts politics aside. Alas my hopes for that happening are slim to none.

[1]: https://www.nytimes.com/2021/06/23/science/coronavirus-seque...


> some sequences appear to have been deleted

That is a completely unrelated issue. The sequences you're talking about are sequences from patients (obtained in February 2020, I believe). They are not bat coronavirus sequences, which is what the poster above you is referring to. The Wuhan Institute of Virology publishes the sequences it discovers. RaTG13, the closest known relative of SARS-CoV-2, was published in 2016, for example.

Even if we're talking about the patient data, even though the authors withdrew their raw data from a database, they still published the most important information in a paper: the genetic sequences.


This is totally related to the Chinese hiding all the data they can related to the origins which suggests there may be a reason for the hiding.

(some details - they even tried to hide the original sequence which our vaccines are based on. When a lab released it against orders they closed the lab. When Australia suggested an independent investigation they put 80bn of trade sanction on them. When a doctor at the start warned his colleagues privately to be careful as the vaccine was contagious they arrested him and made him sign a confession etc etc...)


I feel this is like throwing stuff at the wall to see what sticks:

> they even tried to hide the original sequence which our vaccines are based on.

By the accounts I've read, there was rivalry between the China CDC and researchers at different institutions to publish the genome first, not to hide it. The China CDC was taking longer to validate the genetic sequence and write up a publication, and they didn't want to be scooped. But regardless of the delay this caused, the genome was published extraordinarily quickly - less than two weeks after the first patient test results even suggested that there might be a new virus.


Ok - googling the story on the original sequence seems to have changed. The original reporting https://www.scmp.com/news/china/society/article/3052966/chin... suggested a cover up but a more recent interview with the guy suggests not https://time.com/5882918/zhang-yongzhen-interview-china-coro...


I'm not familiar with genetics, so speaking as a layperson here, but if there was manipulation of patient data why should we consider WIV publications to be truthful and exhaustive? If the patient data had links to unpublished bat sequences the lab was working on, it would certainly be motivation to get rid of both.

Unfortunately any claims pointing in the direction of a zoonotic transfer or lab leak is speculation at this point until serious research is done. And even then the extent of data manipulation might be so deep that drawing any conclusions might be impossible. It's an absolute disgrace that science has become so entrenched with politics that more than a year later we're still not clear on the origins of a world disrupting pandemic.

> they still published the most important information in a paper

Could you link to this please?


There was no "manipulation of patient data." The authors withdrew their raw data from a database, and then published the summary data (what most people will actually want to know) in a paper. The summary data matches the raw data (later recovered from the cloud).

> Could you link to this please?

It's in Table 1 of their June 2020 paper: https://onlinelibrary.wiley.com/doi/full/10.1002/smll.202002...

> If the patient data had links to unpublished bat sequences the lab was working on, it would certainly be motivation to get rid of both.

The patient data had nothing to do with bat sequences. The paper we're talking about was a methodology paper, in which the authors were trying to test a new sequencing technology using recent patient samples. They were not focusing on SARS-CoV-2 origins, and they certainly weren't working with bat coronavirus sequences. I don't even think there's any connection to the WIV here: the corresponding authors don't appear to be affiliated with the institute.


There certainly was deliberate deletion of raw patient sequence data from the NCBI database. See the paper by Jesse D. Bloom that the NYT article references[1]. I would classify this as "manipulation".

The author is also puzzled why this was done if the data matches the published summary in the Wang et al. 2020b paper, but hasn't received any replies from the authors.

This is also interesting:

> Particularly in light of the directive that labs destroy early samples (Pingui 2020) and multiple orders requiring approval of publications on COVID-19 (China CDC 2020; Kang et al. 2020a), this suggests a less than wholehearted effort to maximize information about viral sequences from early in the Wuhan epidemic.

> I don't even think there's any connection to the WIV here: the corresponding authors don't appear to be affiliated with the institute.

The authors of the nanopore paper are associated with Wuhan University. Since the CCP controls all aspects of Chinese research it's safe to say that a connection with the WIV certainly exists and they would be in a position to control the output of both.

Again, the reason behind this will likely never be known to the outside world. But to take anything coming from Chinese researchers as evidence for a narrative that exculpates China from any fault would be extremely naive. Or do we really believe there's nothing suspicious about a country of 1.4bn people having 5,508 reported deaths from COVID-19[2]?

[1]: https://www.biorxiv.org/content/10.1101/2021.06.18.449051v2....

[2]: https://covid19.who.int/region/wpro/country/cn


"Manipulation" means faking data, deliberately altering it, etc. What happened in this case is that the authors removed the raw data from a database and then published an accurate summary of the data in a peer-reviewed paper.

> Since the CCP controls all aspects of Chinese research

Not everything in China is automatically connected to everything else. People working on a new medical diagnostic tool at one university are not automatically related to people doing bat coronavirus research at another institute.

> Or do we really believe there's nothing suspicious about a country of 1.4bn people having 5,508 reported deaths from COVID-19[2]?

I'm sure there are lots of people here on HN who live in China, and who can explain the extremely strict and effective measures China took in early 2020 to eliminate SARS-CoV-2 from within their borders. China had a first wave that was largely confined to one city, and has had no large outbreak since. It's had small, local outbreaks that have been quickly contained. There's really no mystery about this at all.


How do you know 2? It is documented that the Chinese deleted sequences from a global database. Also how naive can we be thinking they have given WHO access to all the research? They didn't. So remove argument 2.


> It is documented that the Chinese deleted sequences from a global database.

You're referring to something completely different, which has nothing to do with bat coronavirus research or the Wuhan Institute of Virology.

A group of researchers working on new sequencing techniques for patient samples (not bat coronaviruses) withdrew their raw data from a database. They then published the key data in a peer-reviewed journal.[1] It's better to have the raw data, but it's not as if the researchers hid their results. And again, this has nothing to do with bat coronaviruses or the WIV.

The WIV publishes the viruses it discovers. They published RaTG13, which is now recognized as the closest known relative of SARS-CoV-2 (but not the progenitor), in 2016. WIV scientists regularly publish papers, give talks at scientific conferences, and collaborate with international scientists. We have a very good idea of what they had and what viruses they were working with. Nobody from the WIV ever mentioned anything that looks like SARS-CoV-2 before the pandemic began.

1. https://doi.org/10.1002/smll.202002169


What about the purging that took place early in the virus (not this most recent "database purge" ... which as you point out may not be the important one.

March 2020:

https://www.thetimes.co.uk/article/chinese-scientists-destro...


You mean the order to either transfer patient samples to more secure labs or destroy them?

That's standard biosecurity when a new, dangerous pathogen is discovered. Regulatory agencies in other countries would have done the same thing.

A bunch of patient samples were sent out to diagnostic labs before anyone knew they contained a novel coronavirus. You can imagine regulators freaking out when they discover those samples contain a new, possibly dangerous virus.


I think you are not familiar with https://www.nature.com/articles/d41586-021-01731-3

And you are talking about something else.


No, I am talking about exactly that story.

From the Nature article you link to:

> The sequences were associated with a paper in which researchers used nanopore-sequencing technology to detect SARS-CoV-2 genetic material in samples from people. That study was published in the journal Small in June 2020, having been posted on bioRxiv in March of that year.

> the sequences Bloom recovered were not hidden: they are described in detail, with enough sequence information to know their evolutionary relationship to other early SARS-CoV-2 sequences, in the Small paper.


I’m not making an argument, I’m summarizing the article. Here’s the relevant sentence:

> The genetic code of SARS-CoV-2 does not resemble that of any virus the WIV was known to be culturing in its lab, such as WIV1


Again, you seem to trust the Chinese administration to their word. I bet during Chernobyl we should have trusted the USSR for information too. And since this famous Chinese investigator said "oh no it wasn't romantic our lab" we should stop digging for the origin of the most catastrophic event since WW2


You're misunderstanding parent's post. Parent is neither trusting nor mistrusting the Chinese administration. They are simply explaining (and quoting) the article.


Then I disagree with both parent and article and taking my opinion which is that we don't know and cant trust what the Chinese say on the subject.


The Chinese can't go back in time and change things they said before the pandemic. The viruses that the Wuhan Institute of Virology works with are fairly well known, because the WIV has published numerous papers on them.

We know, for example, that the WIV has three live coronaviruses that it works with. None of them is close to SARS-CoV-2.

We also know about a whole range of other viruses they've discovered (by sequencing RNA fragments), but which they haven't been able to culture in the lab. These include RaTG13, which they first published on in 2016. It's significant that among all these viruses they've published on over the years, none is similar enough to SARS-CoV-2 to be its ancestor.

I'll just add that some of the people we're talking about here, like Dr. Shi Zhengli, are very highly respected scientists who have contributed a huge amount to the field of virology. Just accusing them of lying with zero evidence is in pretty poor taste.


Did they give full access to all documents and facilities to WHO? NO. Why do you continue an argument that has 0 basis?


The WHO team went to the WIV and got detailed information about the research conducted by the various research groups there, and were able to question the groups.


Tedros said after they returned that he doesn't trust fully the results and they need to keep digging for this possibility. Are you in any way involved? This persistent blindness of facts and distortion of truth is too much for a non interested party.

Google a reference for my first sentence.


Incorrect. The RBD was a 90+ percent match to a pangolin coronavirus, the backbone was 90% + match to a sample collected from bats in Guangdong if I recall correctly, and you had GoF techniques in play that enabled seamless porting of nucleotide sequences that left no traces of gene edits. We've gone over it in previous articles...

Capabilities. Not motivations. Never ever lose sight of that. You will never know what makes another human being tick or do what they do, but you can definitely establish an upper bound on the trouble they can get themselves in to.


A 10% difference is massive for a 30k-base virus. In the public mind, "gain of function" has gained the aura of some sort of black magic, but creating SARS-CoV-2 from any combination of known viruses is beyond the capability of any lab. The amount of effort you'd have to put into it would be astronomical, and all for no apparent scientific reason. This line of speculation really is completely separated from reality.


I recommend taking the time to read the article, they cover this pretty well.

It seems that even of this were manufactured, it is not likely intentional.

>The Chinese research did not have the specific goal of making the viruses more deadly, and rather than SARS itself, it used SARS’s close cousins, whose real-world risk to humans was unknown—in fact, determining the risk was the point of the research. Just as when you trade in part of a poker hand for fresh cards, there was no way of knowing whether the final chimeras would be stronger or weaker.


The problem for this speculation is that given the types of experiments the WIV is known to have done, it is impossible to produce anything that looks remotely like SARS-CoV-2. The reverse genetics system used by WIV researchers is well known, and SARS-CoV-2 is simply not a product of it.


https://project-evidence.github.io/

https://archive.is/tpxg1 Nicholas Wade's excellent medium post, one hundred percent worth the read, Possibly duped in the Bulletin of atomic scientists shtick floating around right now.)

>https://archive.is/ONgMa Yuri Deigin's excellent write-up

I'm hedging the percents because my quick reference of previous post's substances is on my other phone, which died horribly, and having to play the "Dude, I had it elsewhere card, I swear" card is my punishment for shitty backup hygiene.

These are two of the better write-ups I've seen and deep dove into, and project evidence is a staple that's only gotten more and more confirmed with the number of eyes that have gone into it despite their initial total flub up of picking a name for it.

There is more than enough know-how condensed between Baric and Zengli Shi to swap RBD's and insert Furin cleavage sites without leaving traces of having done so. I had one paper that went into a hypothetical process for doing so, but I was an idiot and can't remember the author, and it wasn't the most straightforward search engine query because it was one of those middle of the night, just got done reading another paper, saw a query string that looked promising, did it, and pay dirt. Great when looking for a dopamine hit and ego boost for "haha I found it!"; Not so much for when life happens and you suddenly have to rewalk that mental path.

>_<

This is why I'm not an academic... Or more precisely, this is what happens when you let habits you built during college atrophy because you have a day job now.


> There is more than enough know-how condensed between Baric and Zengli Shi to swap RBD's and insert Furin cleavage sites without leaving traces of having done so.

Baric, Shi and others use particular reverse-genetics systems, which are well known to the outside world. Developing a new system is a significant effort. They don't just swap RBDs or spike proteins into random viruses that nobody has ever heard of before.

SARS-CoV-2 is an entirely new virus, different throughout its entire genome from any previously known virus. An engineered virus would use a known backbone, such as SARS-CoV or WIV-1.

Keep in mind that neither Wade nor Deigin actually has any expertise in virology, and it shows. Rather than listening to laypeople shooting from the hip, listen to what actual virologists have to say. Here's Kristian Andersen and Robert Garry on TWiV: https://youtu.be/Hez3xNv2ido



This type of comment is what I come to HN for. Thank you.


Have an surprisingly excellent article in the new republic while you're here:

https://newrepublic.com/article/162689/bats-covid-19-lab-lea...


This part of the article citing Anthony Fauci's 2012 comment [1] is impressive to me:

“Consider this hypothetical scenario,” Fauci wrote. “An important gain-of-function experiment involving a virus with serious pandemic potential is performed in a well-regulated, world-class laboratory by experienced investigators, but the information from the experiment is then used by another scientist who does not have the same training and facilities and is not subject to the same regulations. In an unlikely but conceivable turn of events, what if that scientist becomes infected with the virus, which leads to an outbreak and ultimately triggers a pandemic?”

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484390/


An interesting aspect of the evolution of the lab leak theory is the unhealthy relation of mainstream media to scientific research. When the Andersen paper came out conflating the lab leak theory with the crazy bioweapon theory and lumping both as conspiracy theories, all mainstream medias jumped on this and used it for several month to quash discussion of the lab leak theory. The most vocal were the "science correspondents" and "decoders". I suspect this is because it's the kind of people that are sufficiently interested in science to have a healthy respect for it, but not sufficiently involved in science to have the healthy skepticism towards published papers. People that do publish and review scientific papers are well aware that published papers are just additional evidence for a theory, not a golden source of truth, but that seems largely lost on mainstream media. Especially when they can use it as anti-Trump material. For anyone interested in a balanced scientific view on the lab leak theory, Alina Chan on twitter is amazing.


I second your recommendation of Alina Chan, as she has the scientific credentials, is careful with the science, and as you say is balanced in that she doesn't dismiss the natural origins hypothesis either. If people want to be informed about multiple perspectives of this debate, she is a must-follow.

That said, let me temper that with some skepticism. First, having got a book deal[1] she is now in the position of directly financially benefiting from media promotion, which in my opinion puts her in a slightly different category than a purely objective scientist.

Second, while she is careful that her words are always defensible and rooted in science, my interpretation of her (prolific) memes is that hell yeah, she thinks it's a lab leak. I want to emphasize that this is my interpretation; at worst, she can be accused of communicating ambiguously enough to create this interpretation in a cross-section of her audience. And a large fraction of her replies are people who are, shall we say, less scientifically careful.

Third, she has truncated quotes from her detractors in a way that changes their meaning, and I find this not entirely good faith. Here's the thread[2] that has that quote and Dr. Rasmussen's response. Perhaps this is an honest difference in interpretation, and Dr. Rasmussen is being too thin-skinned about it.

In any case, my goal here is to present evidence which I think might be relevant, and encourage people to look at it and decide for themselves. As I say, while for the reasons I cited above, I certainly wouldn't consider everything Dr. Chan says to be gospel and accept it uncritically, I absolutely agree that hers is a voice that should be heard. Much to her credit, she has been consistently calling for a real investigation for a long time, well before it was newly fashionable.

[1]: https://twitter.com/Ayjchan/status/1402374919481180167

[2]: https://twitter.com/Ayjchan/status/1410653757617152005


Thanks for pointing that out. I agree with your first point about the book deal.

On your second point, she has stated repeatedly and explicitly that her position is that she doesn't know what the origin of the virus is, natural origin is not ruled out either, and that all she is asking for is that both theories are credibly investigated, for example here [1]. Of course she talks a lot more about the lab leak, but that's largely because she feels this side has not been discussed sufficiently, which was certainly true until 2/3 months ago.

On your third point, you're right that she truncated the quote, but I think her interpretation is the one many readers would come to: "lab leak=conspiracy theory". The quote is dishonestly structured to start with, lumping together lab leak with 5G/Bill Gates silliness. It's the same mistake that the Andersen paper made lumping lab leak with bioweapon. I wouldn't count that as a win on either side.

[1] https://twitter.com/ayjchan/status/1411049136762327043?s=21


I just read Alina Chan profile news on local news. It is mention that her background is in genetic therapy. How seriously I should take her statement on covid based on her background?


I'd encourage you to read what she says before you decide. Her background should make you take her more seriously that if she was, say, a software engineer, but less seriously than if she was a virologist. But for me, her background is only one factor in my decision of how seriously I take her. A bigger factor is how serious, informed and reasonable what she says is.


I'd absolutely give her this one. This is the relevant line from LinkedIn:

> Investigating the effects of human genetic variation on the efficacy of adeno-associated virus (AAV) variants in order to engineer gene therapy viral vectors targeting diverse patient populations.

So this is professional work at a prestigious institute on (a) viruses, (b) engineering of viruses, and (c) deeper understanding of the dynamics of transmission of these viruses in humans. Further, adenovirus is one that can be engineered to be combined with pieces of SARS-CoV-2 to do interesting things in humans, as I can personally attest, having had the J&J vaccine.

It's hard to imagine a set of credentials better suited to analyzing origins of Covid. There are a lot of grifters out there, "epistemological trespassers" if you will, but Dr. Chan's is a voice that deserves being listened to.


I just read your link [2]. She definitely didn’t fabricate or misinterpret the quote, which says that lab leak + concealed IS a conspiracy theory.

Full quote (as per Dr Rasmussen), and italic parts support the above interpretation:

> Unfortunately, this did little to quell often contradictory and sometimes outright ridiculous conspiracy theories that spread faster than the virus itself: SARS-CoV-2 was the result of a laboratory accident or was intentionally engineered, and this was concealed to hide either spectacular incompetence or a complex international conspiracy involving Bill Gates, the Chinese Communist Party and 5G wireless network infrastructure with an end goal of ushering in a new world order.


> this was concealed to hide either spectacular incompetence

I won't even touch the rest, but this one still strikes me as too early to call, given the cultural importance of saving face. I'll buy that there was much less of it than people allow their imaginations to run away with it, but if you don't think there was some very long tense, sweating bullets meetings on how to best go about sculpting the narrative and shaping the story in terms of national interest goes, or covering of ass in the early days, then I don't think you've been paying attention to the diplomatic realities surrounding China at all.


This article has a number of issues that jump out to me from just a cursory read.

The author admits that the NIH has a specific definition of "gain of function research" and then seems to go forward with the article using their own definition, without calling out that they're doing this. Why are they using their own definition instead of the NIH's?

The Chinese research this author cites claims that there are large reservoirs of virus's in bat populations that are currently able to cross into the human population with minimal, if any, mutation required. This makes a natural crossover event more likely compared to the lab-leak hypothesis. This point seems to escape the author entirely.

Next, this whole paragraph is a mess:

> The revelation that the WIV was working with SARS-like viruses in subpar safety conditions has led some people to reassess the chance that SARS-CoV-2 could have emerged from some type of laboratory incident. “That’s screwed up,” the Columbia University virologist Ian Lipkin, who coauthored the seminal paper arguing that covid must have had a natural origin, told the journalist Donald McNeil Jr. “It shouldn’t have happened. People should not be looking at bat viruses in BSL-2 labs. My view has changed.”

There are multiple topics that are being jumbled up. The surrounding context has been heavily discussing genetic engineering research. Ian Lipkin's paper discussed a virus with natural origins. The linked article is discussing the possibility of a lab-leak. These are all different topics and no attempt is being made here to distinguish and collate them. The linked article doesn't make it clear on whether Lipkin changed his view on the virus being of natural origin or of possibly being leaked from a lab or even something else.

In fact, this whole article can't seem to distinguish between the hypothesis of an engineered virus escaping a lab, and a naturally occurring virus escaping the lab. The article ends by belatedly admitting that Baric believes that a natural spillover is still the most likely explanation but devotes zero space to explaining why. Instead, the author sees fit to spend the rest of the article explaining why Baric thinks WIV should be investigated further.

To many of these lab leak articles are structured distressingly like a Q-drop: "Look at all these facts that I'm going to recite in a spooky tone of voice but not bother to synthesize into a coherent hypothesis. Isn't it spooky?" It's not clear to me if it's because the author is writing high-brow clickbait, is unable to recognize these flaws, or is deliberately trying to sling conspiracies. The lab leak hypothesis should be investigated, but not like this.


To many of these lab leak articles are structured distressingly like a Q-drop:

Similar to the way the Zoonotic link articles are structured as the Ultimate Truth which must not be questioned (even as early as one month into the pandemic).

It only took a year later for prominent blue tribe members like Jon Stewart to point out how ridiculous the dominant narrative was.


You read the article poorly. The gain of function language is perfectly within context.

Also, how can you even write sentences like

>This makes a natural crossover event more likely compared to the lab-leak hypothesis. This point seems to escape the author entirely.

And in the very next paragraph quote all of the points the author was making. Specifically that a crossover event is entirely possible because the scientists were working in sub-standard conditions.

The point you missed is that you don't need centrifuges and lab equipment for this to happen, just a place where lots of source material is stored and people not using proper safety precautions.

I'd recommend giving the article a second read, it's the best article I've read on the subject to-date.


I've made up my mind to discount the lab escape hypotesis as it's likely to generate more yellow journalism and controversy fueling the "news cycle", conspiracy theories and finger pointing. I guess we'll find the truth in another five or more years.


It took...what, fifteen years to find the tentative source of SARS in the wild(https://www.nature.com/articles/d41586-017-07766-9)? Good luck with those five years.


Wouldnt it be better to try to focus on what the truth might be regardless of ideological constraints?


As far as I'm concerned this is the truth until there's enough evidence to support a different theory:

https://www.who.int/publications/i/item/who-convened-global-...


You are seeing these issues because the piece is based on motivated reasoning

The author has more than a few other pieces which helped push the US into invading Iraq back on 2003

And these are the same old tactics which were used to foment the invasion of Iraq in the 90s with things like the unquestioned statements such as "throwing babies out of incubators"


Ad hominem


In this case the discussion is about the author. The point is to assess if the misdirection is deliberate or not


Whether or not the post misdirects, or is false, is unrelated to what the author wrote in 2003.

It's not even established that they were "misdirecting" then, either.


"The Last And Only Foreign Scientist in the Wuhan Lab Speaks Out" [1]

[1]https://www.bloomberg.com/news/features/2021-06-27/did-covid...


But she was working in the BSL-4 lab, and if I understand correctly WIV and SHC014 (coronaviruses) were studied in BSL-2 and BSL3 labs, when a close to BSL-4 lab was needed.


There is no mention of BSL-4 in the article, which really jumped out at me.

And their earlier research was done in BSL-2!


She was at the BSL4 lab. This is different than the BSL2 lab that was speculated to have leaked covid.


Aren't they included in each other like a matrioshka doll?


Doubt it. I'm curious where the BSL-2 actually was.


The new laboratory building has 3000 m2 of BSL-4 space, and also 20 BSL-2 and two BSL-3 laboratories.

https://en.wikipedia.org/wiki/Wuhan_Institute_of_Virology#ci...

But of course the WIV has a few other research centers there.


Does anyone have a link that doesn't explode my phone on opening?


For anyone interested in what these labs look like, the podcast "TWiV" (This Week in Virology) did a video where they visit Boston's BSL-4.

Software engineers might appreciate the simplicity with which redundant failsafes are attained - each Biosafety Level being contained by a less safe abstraction.

Thus a BSL-4 lab is essentially 4 labs built inside themselves, like a Matryoshka doll for pathogens.

https://www.youtube.com/watch?v=tqAjkjGq8Ug


BSL4 or not is not really important anymore, as Dr. Shi did her experiments in a BSL2 lab. From the article:

"Unnoticed by most, however, was a key difference that significantly shifted the risk calculation. The Chinese work was carried out at biosafety level 2 (BSL-2), a much lower tier than Baric’s BSL-3+."

BSL2 is not much more than "wear a lab coat". https://consteril.com/biosafety-levels-difference/

So the nicest BSL4 lab does not help if you do not use it.


BSL-2 is a lot more than "wear a lab coat". If it was just that, there'd be no BSL-1. BSL-2 usually also means doing work in a biosafety cabinet and sterilizing disposals, although the controls employed vary depending on the hazards specific to the actual work being done. If you're interested, Yale lays it out in 200 pages of detail: https://ehs.yale.edu/sites/default/files/files/biosafety-man...


Or for the lazy there's the start of Contagion https://youtu.be/-1di7g4Hm1s?t=31


Very interesting. Apparently the BSL-4 lab is engineered to ensure that that it resonates at a different frequency than the larger structure, for additional safety in case of an earthquake.

https://youtu.be/tqAjkjGq8Ug?t=612


I really hope biologists had much bigger debates about virus modification than the tech community has about ethical AI. It's great that we talk about ethical AI, but the fact that a mistake can't cause a pandemic also puts it in perspective.


Arguably, Skynet might count as a pandemic.


https://www.nytimes.com/2021/06/25/opinion/coronavirus-lab.h...

This is a pretty well reasoned take kn the lab leak hypothesis. We might not know for certain if covid came from the lab in Wuhan but there are enough lapses that took place in that lab that a future pandemic can start from that place


This is the most important point in this discussion. If we find out for certain this virus came from a lab leak or not, it wouldn't much change the probability it could have.

I'd estimate most people can agree the probability of a lab leak of a dangerous virus in any given decade is between 1-20%. Is this acceptable or can we greatly reduce it with policy?


I think the prior record of leaks of any dangerous virus has been more like 80%. But that's mostly existing viruses and not setting off pandemics.


An actual witness to what was happening at the Wuhan lab : https://archive.is/IFDZY


The problem with this whole article is that we know of no suitable backbone virus to use, and we know of no suitable spike-protein sequence to form a chimera which results in SARS-CoV-2.

The experiments done on the SARS-CoV-1 or WIV1 backbone don't remotely get you close to SARS-CoV-2 and you're dealing with centuries of evolutionary difference there.

The RaTG13 virus backbone is also several decades of evolution away from SARS-CoV-2.

Learning how to replicate a virus in the lab is also not simple so they're not going to be doing this with every virus they find. We know they managed to do it with SARS-CoV-1 and WIV-1, but they'd need a reason to undertake it with any other virus.

So you have to assume that WIV has a virus which they found which is similar to RaTG13 which they have never published, and for some reason they jumped straight to making that virus replicate in the lab and creating chimeras, and they also had a previously and still unpublished spike protein which was similar to the Pangolin spike which they used. Then for some reason they didn't do this in petri dishes, but used animals and/or somehow managed to aerosolize enough of it that researchers at WIV got sick from it. This is with a virus that we now know doesn't stick to surfaces very well at all, so the actual accident remains unexplained (they had a party and someone chopped up some chimera and railed it like a line of coke? that'd do it).

While you're pondering all that keep in mind that the person who "broke" the story in the WSJ about the sick workers at the Wuhan lab was Michael R. Gordon. He's also notable for having co-authored with Judith Miller in 2002 the NYT story on Hussein's nuclear program and WMDs that arguably helped propel us into the Iraq War.

It is also worthwhile to read Shi Zhengli's rebuttal to the lab leak theory:

https://www.nytimes.com/2021/06/14/world/asia/china-covid-wu...

If you'd like some actual science on the zoontic investigation:

"Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia"

https://www.nature.com/articles/s41467-021-21240-1

"Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus"

https://journals.plos.org/plospathogens/article?id=10.1371/j...

"Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses"

https://www.cell.com/cell/pdf/S0092-8674(21)00709-1.pdf


Here's a much better article that lays out the argument I'm trying to make pretty much exactly:

"The Case Against the Covid-19 Lab Leak Theory":

https://newrepublic.com/article/162689/bats-covid-19-lab-lea...


Article conveniently ignores the adverse inference angle, which is the most damning. Let’s wait until we see what was actually going on in the lab.


> While you're pondering all that keep in mind that the person who "broke" the story in the WSJ about the sick workers at the Wuhan lab was Michael R. Gordon. He's also notable for having co-authored with Judith Miller in 2002 the NYT story on Hussein's nuclear program and WMDs that arguably helped propel us into the Iraq War.

Uh, are you referring to this [0]? It's the only obvious thing I can find on Google linked to his name.

It was also posted over a year after when we first heard of those sick workers. Here's [1] one example (they're mentioned from 6:30 to 6:50).

[0] https://www.wsj.com/articles/intelligence-on-sick-staff-at-w...

[1] https://www.youtube.com/watch?v=bpQFCcSI0pU


If it was a lab leak it was probably a modification of a natural bat virus that has not been published yet. The published one RaTG13 is too different. Them having unpublished viruses is pretty likely. Either knowingly or as Baric says maybe just getting bat shit on the culture cells containing a virus they weren't aware of.

You could probably check this by going to the bat caves and taking samples which is probably why they pretty much mobilised the military to block the road when some western reporters tried going there.

If the west could every get independent investigators to the Mojang mine I think there's a high chance we'd find the origin.


Yet almost a year later and still no smoking gun showing a clear zoonotic link.

I suppose we’ll never find one because China has no interest in getting to the truth. Cooperation means disclosing things which have the potential to make them look bad so why risk it?


Proving the zoonotic chain of transmission is not a quick or easy thing to do even in a cooperative geopolitical environment. This is not a field that lends itself to snappy "smoking guns". It took years to build the evidence for civet-cats and SARS-1 and we still don't know for certain what the wild ebola reservoir is.


SARS-CoV-1 happened in Guangdong in 2003.

The Bat CoVs that are likely part of its natural zoonotic reservoir were only found in 2013-2016 in Yunnan.


What's missing now is not the reservoir, it's the last link from that reservoir to humans. With SARS, it was fond in less than a year (civets). This time, it remains notoriously missing, despite tens of thousands of animals tested.


I remember in the 1990s reading about expeditions to try to confirm the natural reservoir of Ebola. Apparently we're still trying to figure it out [0, 1]. Covid is subtler and thus harder to track. Definitive proof of origin seems unlikely to arrive quickly or even at all, regardless of who is or isn't acting in good faith.

[0] https://www.cdc.gov/ncezid/stories-features/global-stories/e...

[1] https://www.nature.com/articles/s41598-020-71226-0


This is the best written article up to now in my opinion.

https://www.google.com/amp/s/thebulletin.org/2021/05/the-ori...


An AMP link? You've been on here long enough to know better :^)


This is starting to look quite plausible as the origin of the pandemic, including stuff like:

>Let’s face it: there are going to be unknown viruses in guano, or oral swabs, which are oftentimes pooled. And if you’re attempting to culture a virus, you’re going to have novel strains being dropped onto culture cells,”

So it could have come from the lab without them even knowing. The way to check would probably be to get inspectors to the caves where the guano came from, which annoyingly I doubt the Chinese will ever allow.


I know it's bad thinking on my part, but strong "Cui Bono?" vibes from this article's publication, central claim, and timing.

(ie shortly after the scientific community suddenly revoked it's embargo on the idea that the Wuhan Institute of Virology, which was studying bat coronaviruses, might have had something to do with the sudden appearance of a bat coronavirus in Wuhan that still has no evidence of a natural origin).


Much of the article reminds me of the description of how NASA ended up launching a shuttle in temperatures far below what they originally would have allowed. You walk just past the line, nothing bad happens, so you move the line a bit. You walk just past that line, nothing bad happens...and this repeats until, inevitably, eventually, something bad happens.

Regardless of whether or not this pandemic came from this lab, the industry incentives described in the article can only eventually result in one.

We have a mechanism for dealing with this sort of problem, and it involves outside audits. The "bad thing" involves being slapped down by an outside authority that has teeth behind its recommendations. In order to have authority in places like China, it would also need to have authority in places like the USA, which means a bunch of American (and European) scientists would see their own work get more difficult, as well. This has to make it more difficult for them to decide to think objectively about the possibility that this pandemic came from a lab.


This sort of work should absolutely get more difficult for western scientists too. We’ve had several lab leaks that through luck didn’t turn in to pandemics. Certainly the costs of auditing and complying with lab safety is far cheaper than a global pandemic.


Prominent, respected virologists have been questioning gain of function research for a while. Here's a cite[1] from 2018 from Marc Lipsitch, who would be on most people's top ten list of trusted virologists on Covid. He's also one of the signatories of the letter calling for investigation[2].

I think it's possible to split out the question of bioresearch risks from Covid origins. If it was a lab leak, obviously we should regulate those risks better, but we should also do more to mitigate zoonotic spillover, because we have tons of evidence that happens and causes damage. If it wasn't lab leak, we should do more to mitigate spillover, but it would also be a good idea to be more careful about biosafety.

[1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119956/

[2]: https://science.sciencemag.org/content/372/6543/694.1


> If it was a lab leak, obviously we should regulate those risks better, but we should also do more to mitigate zoonotic spillover

> If it wasn't lab leak, we should do more to mitigate spillover, but it would also be a good idea to be more careful about biosafety

This seems like a roundabout way to endorse Matt Yglesias' view that there are basically no implications to the question "was it a lab leak?"


Very little in the way of public health implications. Quite a bit in terms of geopolitical implications. I do think people confuse the two a fair amount.


If there are no practical implications, why would there be political implications? You don't usually premise your political stances on the foundation that "something irrelevant happened".


Lipsitch is an epidemiologist, not a virologist.


You are right, thanks for the correction!


> Prominent, respected virologists have been questioning gain of function research for a while

The quotation you cite from Lipitsch doesn't validate your comment.

He wasn't "questioning gain of function research". He was calling for greater oversight over gain of function research and for more initiatives to try to limit the damage potential of zoonotic spillover.

If anything, Lipitsch was upholding the value of gain of function research, because he believes scientists should do everything possible to try to prevent pandemics.


Huh? The title of the piece is "Why Do Exceptionally Dangerous Gain-of-Function Experiments in Influenza?" The introduction specifically criticizes entire categories of GoF research, stating that it goes against the consensus view of many virologists. How is that not "questioning?" Lipsitch has been consistently critical in other fora too, including a quote in a Science piece[1], a call for a debate[2], and other communications.

Now, one thing that is going on in a lot of the discussion (and which makes reasoned discourse harder) is that many people mean different things when talking about "gain of function." For some, it's anything that creates a pathogen that's potentially infectious to humans, which potentially covers a lot of experiments to test transmissibility and other factors. For others, it has to be specifically engineering to increase transmissibility or virulence [3]. That can lead to confusion, for example the debate about whether Fauci's denial that the NIAID funded GoF research was honest.

I very carefully check my sources when posting, but am sure I make mistakes. When I do, I'm happy to be corrected. But this seems a very odd thing to call me out for.

[1]: https://www.sciencemag.org/news/2019/02/exclusive-controvers...

[2]: https://www.researchgate.net/publication/269283247_Gain-of-f...

[3]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996883/


Oh I see. I didn't follow your links, rather I thought your second para was the quote.

"I think it's possible to split out the question of bioresearch risks from Covid origins. If it was a lab leak, obviously we should regulate those risks better, but we should also do more to mitigate zoonotic spillover, because we have tons of evidence that happens and causes damage. If it wasn't lab leak, we should do more to mitigate spillover, but it would also be a good idea to be more careful about biosafety."


Nope, apologies if there is any confusion. That's just my opinion. I'm basically trying to make the point that this overfocus on origins is more of a political question than one with direct public health impact.


Yes, I can see from your comment that you are interested in public health.

The over focus on origin is clearly a proxy for something else.


> is far cheaper than a global pandemic

It’s hard to overstate the case here. Even a tiny chance for a proposed research project to causing something like covid 19 has a gigantic risk adjusted cost and should only have been undertaken if the expected results were likewise enormously beneficial.

Something seems off with the cost benefit analysis in these laboratories.


The whole point of research like this is to better understand a naturally occurring risk of disease. Without the work to understand in detail how similar coronaviruses infect humans cells, there is no way Moderna and BioNTech could have turned around their mRNA vaccine candidates as fast as they did.

When looking at cost-benefit analysis you have to understand that the probability of a naturally occurring human infectious disease capable of causing a pandemic is 100% over a long enough time span. Therefore the possibility of a lab leak can add little marginal risk over that same period of time. Whereas the understanding that comes from research will confer benefits no matter the origin of the disease.

Labs should be as secure as possible: yes. But there is a huge opportunity cost to saying “don’t work with human infectious diseases any more.”


If it adds little marginal risk, why bother with any secure labs?

Following your "gonna happen eventually", let the scientists play with their toys under tents in the public square.


If you run a secure lab, you don’t accelerate the onset of a potential pandemic. If you run an insecure lab, you might accelerate the onset, which is bad.

My point is that ceasing research entirely does not rule out a future pandemic, but it certainly would harm our ability to respond to a future pandemic.


> Without the work to understand in detail how similar coronaviruses infect humans cells, there is no way Moderna and BioNTech could have turned around their mRNA vaccine candidates as fast as they did.

Can you provide a reference for this?


I’d also like some evidence for this. If moderna or biontech researcher were specifically using knowledge from gain of function research that would shift my view on the cost/benefit analysis.

So far all I’ve seen is a bunch of handwaving about “advancing the science.”


Well sure but:

(1) this pandemic has not been shown to be caused by gain-of-function research and probably wasn't.

(2) why do you think scientists do gain-of-function research? It's to try and prevent pandemics by finding viruses which might be dangerous.

So if there's a problem it's really (3): we haven't consistently funded pandemic preparedness, in particular there needs to be an established process to clinical trial and test new vaccines against identified "risky" viral strains in the wild, ideally with a platform perspective that we can have confidence can be rapidly modified to get a new vaccine out the door.


Much of this reminds me of how we went to war against Iraq

The lead author of the WSJ piece on the "sick lab workers" is the same author that helped get us into Iraq with a NYT article on Hussein's nuclear WMD program in 2002.


It’s almost like those two pieces are completely unrelated to one another.

If you’re looking for someone with a clean record commenting on the viability of the lab leak theory for months, take a look at Bret Weinstein.


For well over a year. If folks don't know, in the third month of the pandemic he did a long form discussion with a geneticist about the surprising genome snippets found in the base coronavirus strain that the wuhan lab obtained from a bat cave in Hunan. They discuss gain of function practices at that lab and others. None of this discussion is new.


The furin cleavage sites have now been pretty decisively debunked.

They're found not only in many other coronaviruses, but they've independently evolved over 6 times that we know about, and they've now been found in SARS-CoV-2 related sarbecoviruses in bats.

The goalpost moving has migrated to arguing that a couple of sequences in the furin sites are now "unusual". Kristian Andersen, whose early 2020 e-mail to Fauci has been passed around as evidence of the lab leak theory has more recently talked to the NYT about this:

> Furin cleavage sites are found all across the coronavirus family, including in the betacoronavirus genus that SARS-CoV-2 belongs to. There has been much speculation that patterns found in the virus’s RNA that are responsible for certain portions of the furin cleavage site represent evidence of engineering. Specifically, people are pointing to two “CGG” sequences that code for the amino acid arginine in the furin cleavage site as strong evidence that the virus was made in the lab. Such statements are factually incorrect.

> While it’s true that CGG is less common than other patterns that code for arginine, the CGG codon is found elsewhere in the SARS-CoV-2 genome and the genetic sequence[s] that include the CGG codon found in SARS-CoV-2 are also found in other coronaviruses. These findings, together with many other technical features of the site, strongly suggest that it evolved naturally and there is very little chance somebody engineered it.

And "surprising genome snippets" don't get you past the fact that the closest known relative to SARS-CoV-2 is still decades of evolution away from being SARS-CoV-2 which is not something that can be engineered in the lab.

See this article for a lot more:

https://newrepublic.com/article/162689/bats-covid-19-lab-lea...


I took a look at Bret Weinstein, and it wasn’t good. Not good at all. He seemed to be making every effort he could to blame the mRNA vaccines for problems that —if true— could have any number of mundane explanations. But hey, maybe he’s right about the lab leak theory.


Yeah sadly he's gone off the deep end on "spike protein", but he has been a good fount on the origins of covid.


I'm curious what makes you think he's "gone off the deep end"?


He had an academic guest on his podcast that was stating that the spike protein in covid vaccines causes damage the same way that the spike protein in the virus itself causes damage, when the vaccine creators specifically took measures to make the vaccine's version of the spike protein safer and less damaging to cells.

In general there's a fine line to walk with being cautious around vaccines vs 100% assuming they are safe, but he got it wrong with the guest he had on talking about cytotoxic spike proteins in the vaccine. At least that seems to be the overall scientific consensus that I've seen (but who knows! it's a rapidly evolving topic!).

Relevant:

" “The sound bite ‘SARS-CoV-2 spike protein is toxic’ is not technically wrong—also not news at per se—but that has nothing to do with overall established safety of SARS-CoV-2 vaccines, especially the mRNA vaccines,” Lee said.

That’s in part because, according to Machamer, the spike protein in SARS-CoV-2 is different than the spike protein created after the administration of the mRNA vaccines.

“The vaccine, at least the Moderna and the Pfizer vaccines, the mRNA vaccines, they supply the information to make spike, but it’s not exactly the spike that’s in the virus,” she said.

“There are changes that were made on purpose that would prevent the spike protein from being able to undergo binding to the receptor and fusion,” Machamer explained. “And so, all this business about toxicity that has been shown for the real spike protein, the one that doesn't have that block, is totally irrelevant for the vaccine.” "

Source: https://www.verifythis.com/article/news/health/coronavirus/v...


bret and his brother eric have made a name for themselves as contrarians. right or wrong they will take a hot take on whatever hot topic is available and do the podcast and tweet tour with it, all the while screaming to their millions of listeners how they are being silenced.


His ivermectin stuff is pretty wild.

Also, he and his brother have (IMHO) quite obvious inferiority complexes about their academic careers. So much of what they both say boils down to how the academic system doesn't respect their intelligence, and implied is that they deserve it.

I mean, who doesn't feel that way about their field? But to speak at length on podcasts about it, which are only popular due to Joe Rogan and Jordan Peterson, is pretty exhausting to me.


I listened to a couple of Bret’s own podcasts after he was a guest on Lex’s show. I think it’s important to be able to discuss this stuff (origins of the virus, emerging therapeutics, potential risks or adverse effects of vaccines) freely without being censored by YouTube. It shouldn’t be censored and some of these ideas may turn out to be correct. In the meanwhile, I’ll happily take an mRNA vaccine based on my own personal/public health risk analysis.

That said, I take everything he and his brother Eric say with a large pinch of salt - they are clearly both very intelligent but I don’t like this cult leader like absolute certainty of their own ideas and the audience (and revenue) building based on controversy and semi-conspiracy. I think it’s essential to have many voices though so I welcome what they are bringing in to the mix, but personally for me it gets tiring after a couple of podcasts.


The academic guest was Robert Malone and he invented the MRNA vaccine.

He is more than just an “expert”

He made the claim that the spike protein is cytotoxic. He notified the FDA

And FDA has claimed it is not without any evidence


Look I'm not anti vaxer here but to Bret's points, entries into the physician's VAERS database as well as the UK's equivalent already show it's the deadliest vaccine in history. Even v chief of medicine at Baylor is warning the same thing that the membrane spike proteins (and lipid nano particles) are unexpectedly breaking off, circulating, and triggering immune reactions throughout the body. The fact groups about adverse reactions have been removed from FB and that data is not being collected in any systemic way by public health authorities, it's not a stretch to conclude there might be problems with the vaccine and our approach to monitoring.


VAERS does not show it is the deadliest in historical.


Which vaccine is more deadly?

Reported minimum 6k deaths and double that in UK, only a minimum because the standards for incontrovertible linkage is high and fwiw Bret and co hear from physicians who claim their reports aren't being accepted.

The rates are higher in younger people than in covid deaths.

Clinical trials are halted after 1000x less death.


That is nonsense


I like the term "normalization of deviance" and would recommand the Mike Mullane's talk on the Challenger disaster [1].

[1]: https://youtu.be/Ljzj9Msli5o


Does NASA have outside auditors with a highly adversarial relationship reviewing its launch procedures?

I don’t think it does.

I’m pretty sure NASA has an excellent internal team of quality control specialists. The specialists are a part of all aspects of deployment and launch.

They don’t just pop in and review work, they’re constantly there.

They’re also very much “part of the team.” They don’t strictly speaking “have teeth.” They’re focused on the same mission everyone else is, only with a special focus on making it happen safely.

Maybe you mean something like the relationship between the FAA and airline industry.

But that’s very different from how NASA operates.

So it’s clearly not the only model.


The whole saga with the outside oversight is also a complete red herring. USA would never sign a treaty that required them to show their own facilities.

Case in point: biological weapons convention. A few years back there was a very popular proposal to add “teeth”, i.e. random inspections and stuff. Guess who bailed out and passed a Hague invasion act instead?

EDIT: grammar


I have trouble imagining what an external auditor established in China would look like. A worldwide rating similar to credit ratings, where failing to play the game correctly results in sanctions? If China's IP history has shown us anything, it's that they will do whatever they want with reckless abandon.


It could look something like nuclear inspectors. Every country in an arms control treaty gets to send their inspectors in to verify adherence to the agreement.


It's easy enough to apply outside audits to something like Space Shuttle development, where the goals are not secret and it's pretty well understood what you are trying to accomplish and what your capabilities are. It's a very different situation when it comes to bioweapons research -- how do you let outside auditors into Fort Detrick without running the risk of giving some game away?


Neither we nor China are supposed to be doing bioweapons research in part because all examples thus far are impossible to target and destroy women, children, and civilians indescriminately far too slowly to prevent retaliation with swifter means of dealing death.

If anyone is researching this I support their change of address to prison.


While it is certainly true that outside auditors (with enforcement authority) would never be allowed into a bioweapons lab of either China or the USA, it also doesn't really seem to be the case that the virology lab in Wuhan was a bioweapons lab. Most labs doing this kind of research are not bioweapons labs. Moreover, due to the national security implications, bioweapons labs tend at least to have good security about letting stuff out, if for the wrong reasons. If we had outside auditing of all non-bioweapons labs doing this kind of research, it would still greatly reduce the collective risk, if only because that would be most of the labs.


Youtube is still censoring this topic. Two well known scientists testified before congress on GoF testing and the Corona Virus characteristics. That was pulled down within a few hours. I save all these videos but no idea what to do with them.

[Edit] I found a copy of the coverage posted by Forbes [1] and as a matter of correction it is the GOP House Oversight and Reform Subcommittee on Select Coronavirus Crisis hearing

[1] - https://www.youtube.com/watch?v=YeW5sI-R1Qg


This is hilarious and ridiculous. How can they justify censoring testimony in Congress?


Supposedly it is not in alignment with the Trusted News Initiative (TNI) [1] or so people say. No idea if that is the real reason.

[Edit] In this case I am thinking maybe Forbes had exclusive coverage and the other videos were pulled down for not having the rights to coverage. Just guessing because their upload is 3 days old.

[1] - https://www.bbc.com/mediacentre/2020/trusted-news-initiative...


It depends on what you believe the purpose of YouTube is. Just because it's congressional testimony that doesn't mean it's actually credible or vetted information. We have elected officials in the US regularly spouting absolute nonsense, so it's not implausible that the same people would also bring witnesses in to spout the same absolute nonsense, whether it's vaccines causing autism or something else.


Well, they recently did this too: https://news.ycombinator.com/item?id=27646686

I don't know if it's following their policies to the legal letter or if there's something else going on, but it's clearly bad in both of these cases.


That's like saying a civil engineer gave testimony before congress about the Boeing MAX planes. Witness's before congress are chosen for political function, it doesn't give them any sort of automatic credibility.


Okay. But this is still an actual congressional testimony for public consumption by our elected officials. By what reasoning should we not be allowed to see it?


Blanket ban. Even mentioning coronavirus can get your video demonitized. YouTube and Facebook have a significant problem of actual artificial conspiracy theories that have contributed to real death.


You mentioned this twice. "Contributed to real death." What do you mean specifically? Don't just use it as a scare quote.

It's not a good enough justification anyway.


Ashli Babbit, officer sicknick, and a few others all died due to a conspiracy theory spread on Facebook. Many others are threatened every day because of these conspiracy theories.


By this reasoning you could call critical race theory a conspiracy and say it "contributed to real death" through the 2020 summer protests and riots.


Untrue, but also off topic.


Stephen Quay is a "well known scientist" in a field completely unrelated to virology. He's a medical doctor who also does oncology research. Despite admitting to having no experience with Bayesian inference, he produced a "Bayesian analysis" of the origins of SARS-CoV-2. Another person who testified at that hearing, David Asher (also not a virologist, or even a scientist, but rather a former State Department bureaucrat), has been trying to argue for a year that SARS-CoV-2 is a biological weapon designed by the Chinese military.

The connection between Asher and Quay is that during the Trump administration, Asher led a group trying to prove that SARS-CoV-2 was a bioweapon. Asher refused to go to actual subject-matter experts, and instead had Quay do his "Bayesian analysis." When Asher was finally forced by another official to bring scientists with relevant expertise in to go over his evidence, they tore it to shreds.[1]

These are simply not credible people to be getting your scientific information on SARS-CoV-2 from.

1. https://christopherashleyford.medium.com/the-lab-leak-inquir...


In response to the claim "YouTube it still taking down videos claiming X", you reply "This video featured someone not credible."

Are you claiming that YouTube's policy is to take down all videos with non-credible speakers? Or that YouTube judged that the arguments made in this particular video did not meet their standards?


I replied in response to

> Two well known scientists testified before congress on GoF testing and the Corona Virus characteristics.

I'm not commenting on YouTube's policy. I'm commenting on the fact that the people giving testimony are not at all credible. It says a lot that Congress invites obvious cranks to testify, rather than scientists with relevant expertise.


I stand corrected. Is any of what they said accurate?


I haven't watched their Congressional testimony, but I've read Quay's "analysis" and heard Asher propound on his bioweapon theory elsewhere.

Quay's analysis is not a rigorous Bayesian analysis in any sense. It's a series of subjective judgments about likelihoods of various scenarios. It's classic garbage-in, garbage-out, dressed up as science by using the word "Bayesian." The thing is, Bayesian inference is only as good as the information and knowledge you put into it. Quay treats cancer patients and invents medical devices. He has no idea what he's talking about when it comes to virology. It's incredibly telling that he's the guy that pro-lab-leak congresspeople invite to talk, instead of an actual virologist.

Asher is just a career political hack with no scientific background.

Edit: Right off the bat, Quay's first claim in his testimony is highly dubious. He claims that the Huanan Seafood market was not where the virus spilled over, because supposedly the earliest version of the virus wasn't found in patients who were at the market. Two problems: 1. We don't actually know which is the oldest lineage of the virus. 2. Only a tiny fraction of people who got sick at the market have had samples taken. Probably hundreds of people at the market caught the virus and had mild or asymptomatic cases. We only have a few samples, from people who fell seriously ill. By the way, mortality evidence independently supports the Huanan market as the area of the first major outbreak.


One problem for the wet market theory is that neither bats nor pangolins were sold at that wet market:

https://www.nature.com/articles/s41598-021-91470-2

"Here we document 47,381 individuals from 38 species, including 31 protected species sold between May 2017 and November 2019 in Wuhan’s markets. We note that no pangolins (or bats) were traded, supporting reformed opinion that pangolins were not likely the spillover host at the source of the current coronavirus (COVID-19) pandemic."

That doesn't mean there couldn't be a zoonotic explanation, of course, but it does significantly complicate the main alternative to the theory that WIV was doing coronavirus research in humanized mice and that escaped from the lab.


> One problem for the wet market theory is that neither bats nor pangolins were sold at that wet market

That's not a problem for the theory. SARS did not come directly from bats (or pangolins). It went through civets first, which were sold at markets. That's why SARS first showed up in Foshan, 1000 km away from where the bats that harbor the ancestral virus to SARS live.

The Nature paper you linked shows that live animals that are known to be susceptible to SARS-CoV-2 were sold at the Huanan Seafood market. Because of that, the paper has been generally received as strongly supporting the idea that the outbreak began at the Huanan market.


Can you give more data on that? Last I knew, the animal reservoir wasn't identified, has that changed recently? We have a wild animal population infected with Covid-19?

I would revise my assessments if we have a clear animal reservoir, but I need to see more data on that first.


The intermediate host hasn't yet been identified, but the site of the first known outbreak was a market where wild animals were sold, exactly like with SARS. On the other hand, there's no evidence that links the outbreak to the lab in any way.


That goes back to seeming odd to me. We know all the animals there thanks to a comprehensive survey and prior outbreaks didn't take even half this long to find.

And several lab workers did get sick early on. We'll likely never find solid proof one way or another at this rate, though, unless an animal reservoir is found.


> We know all the animals there thanks to a comprehensive survey

The people surveying which animals were there were not from the government, and were not studying coronaviruses. They're conservationists, and it's coincidental that they did this survey just before the outbreak.

> And several lab workers did get sick early on.

So the US government claims, without providing any evidence.

> prior outbreaks didn't take even half this long to find.

That very much depends on which outbreak we're talking about. The intermediate species for SARS was found within about a year, but how Ebola spills over is still elusive, decades after its discovery.

Unlike with SARS, this time around, the Chinese government closed the market down quickly, and also quickly shut down the wildlife farms and culled their stock. That might possibly make finding the intermediate host more difficult.


Sure, but knowing the species and origins of the animals gives us a good overview of what's there. It's weird, but not impossible, that we haven't found it given that. If China had been more forthcoming--and had kept samples from the culls--we would likely have more answers.

Regarding the researchers, there were videos by some people in China who later vanished. I know that China is usually China, but that doesn't exactly make me trust them more.


> If China had been more forthcoming--and had kept samples from the culls--we would likely have more answers.

It's entirely possible that the people ordering the culls and the people carrying out the scientific investigations are different and don't talk to each other. From what I've heard, the wildlife trade was shut down very quickly after the outbreak was discovered. This is a bit like the Huanan market: it would have been scientifically valuable to keep it as-is and do a thorough study, but once the authorities discovered there was an outbreak there, they immediately ordered it to be closed and decontaminated - which makes sense from a public health point of view.

Anyways, there has been a lot of extremely valuable research published over the last year+ by Chinese researchers on the origins of the virus (we now know a lot more about the family of viruses that SARS-CoV-2 belongs to, for example), and I think progress will continue to be made.


There are actual virologists who support the lab leak theory, but my guess is that Congress is calling him because he is pushing it as an intentional lab leak. There is so far no evidence at all for that, and it doesn't make a whole lot of sense. Biological warfare is like trying to use a grenade as a handgun. Yes it does hurt your opponent, but...

Yes China did seem to contain COVID well, but if it were (hypothetically) a bio-weapon there's no way they could have known ahead of time they'd be this successful or that the virus wouldn't mutate into something far more dangerous. The CCP can be evil but they're not reckless. They prefer a very measured, calculated, incremental approach, not high-risk gambits like releasing a bioweapon. If that backfired it could decimate their population, drag them into WWIII, or both, and none of that would be a win.


> There are actual virologists who support the lab leak theory

Very few. I don't know of any major virologist who actually says it's more likely, and the overwhelming majority say it's highly unlikely.

Right now, everything points to the outbreak being associated with animal markets, just like SARS.


Using quantity like this to prop up your reasoning and discounting the contributions of someone outside of a field both weaken the strength of your conclusions, unfortunately.


When people who know what they're talking about say one thing, and people who don't know what they're talking about say the opposite, who are you going to listen to?

There are very good reasons why virologists think SARS-CoV-2 spilled over naturally. I've discussed some of the reasons elsewhere in this discussion (there's absolutely no evidence the WIV had this virus before the outbreak, and there's pretty good evidence they didn't, dangerous human-animal interactions outside labs are vastly more common than in labs, the first outbreak was centered on a market that housed live animals).



TIL - "Founded at the Massachusetts Institute of Technology in 1899, MIT Technology Review is a world-renowned, independent media company whose insight, analysis, reviews, interviews and live events explain the newest technologies and their commercial, social and political impacts."


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This wasn't a biological weapon.

Gain of function research was being carried out for the benefit of society (or resume padding). However, it wasn't subject to oversight (to put it mildly) and was being handled by a lab ill-equipped to do so safely.

China has massive zoonotic reservoirs. The US researchers that led the world in Coronavirus study wanted to do gain of function, but couldn't do it domestically and didn't have access to the wild novel coronaviruses.

Money and notes changed hands, and the Wuhan lab went about gain of function research. The lab was sloppy, the modified virus leaked, and the rest is history.

There are probably only a handful of people ultimately responsible for this. The individuals from the US writing the proposals and pushing for it despite lack of safety, and those in China that knew the risks but went ahead. (The coverup and slow responses are also to blame for the spread.)

Millions of deaths out of lack of oversight and desire for personal prestige. That's the story.


The lab was sloppy, the modified virus leaked, and the rest is history.

That is the most likely explanation, and it is unfortunate you are getting so heavily downvoted.

There are probably only a handful of people ultimately responsible for this.

Again, how much do lab assistants make? I know it’s not a lot in America, and even less in China. I wonder who the person was cleaning bat poop, feeding them, etc. Some underpaid lab assistant, on their 1000th time ferrying bats in and out of cages, cleaning shit, slacked on a particular day. Your 1000th time flipping that Wendy’s burger, and it drops to the floor, and you wipe it off and say ‘fuck it’ and put it on the bun.

Simple as that. No mega conspiracy.


So then everything this scientist [1] says about the lab is a total lie?

`There were strict protocols and requirements aimed at containing the pathogens being studied, Anderson said, and researchers underwent 45 hours of training to be certified to work independently in the lab.`

Your Wendy's burger example is extremely naive as it compares two very different work environments. I highly doubt you could simply walk in and get a job at the lab as you can at a fast food outlet.

Fact is none of us were in the lab and China haven't done a very good job being open and honest about their research there. But I really don't think propagating this simplistic idea that it was a lab leak is fair on anyone.

[1] https://www.bloomberg.com/news/features/2021-06-27/did-covid...


To think that a few months ago, sharing this article would have gotten someone banned from Facebook for sharing "conspiracy theories".


Indeed. The whole thing needs to be looked at. Someone somewhere decided that the topic was taboo and needed to be purged from the internet, and then someone somewhere decided that it was ok that the tpoic gets to see the light of day.

It's all quite sinister.


Don't use Facebook


YouTube among with many other places are even now censoring it so acting like it's a Facebook problem is counter-productive.


So use Vimeo, Peertube, your own web site, ...


> your own web site

What about all those times internet infrastructure companies shut down the people who built their own website? Do you see the precedent that you're setting?


All those times? How many times? Thrice?


Once is enough because it sets a precedent. But AWS taking down Parler is an example, as is AWS taking down America's Frontline Doctors. You may not like those websites, but if it can happen to them, it can happen to anyone.


We should develop open source decentralized alternatives to it that are easy to use.


Honestly I think Mastodon is already about as easy to use as possible. The real problem is the network effect, and the fact that the average person really just doesn't care enough about the benefits you get from it. What we really need is a libre, decentralized social network that's "cool" enough that non-tech people would have FOMO if they don't join. That's a much harder problem, one that I certainly won't be able to solve any time soon.


> Honestly I think Mastodon is already about as easy to use as possible. The real problem is the network effect, and the fact that the average person really just doesn't care enough about the benefits you get from it.

I care a great deal about the benefits of Mastodon! For me, the benefit is that anyone who is obsessive about conspiracy theories, racism, etc have a quarantined social space where they can converse without me having to listen.



Hahaha I agree with my sibling - I went on a ride with bitclout and enjoyed the camaraderie, but immediately saw how petty people were going to get over losing a buck, ironically ready to call other users scammers at the drop of a hat.

If they had a different answer to decentralization than a 2MB/minute block size or a media hosting solution that wasn’t just “allow iframes from YouTube and Vimeo” I would have had more faith, but now that I’ve cashed out I see what the sibling sees, target demographic for a influencer-speculation-exchange is very small.


Wow no. That's not going to appeal to normal people.


Mastodon powers Gab. It is as popular a decentralized technology as it can get.


None of us can solve it alone.

First we need good tech, like Mastodon.

Then we need to move our own digital "lives" onto those better platforms, and start encouraging our friends to join us.

For my part, I'm working on a new social app where everything is E2E encrypted [1], so you don't have to trust the server. The main use case is to let parents share photos of their kids in a safer way. I'm hoping this will be a big draw for people who have currently checked out of the creepy ad-tracking platforms.

[1] https://github.com/KombuchaPrivacy/circles-ios


It won't change anything. This isn't to do with facebook per-se, you'd just get "unlinked" from whatever arbitrators or aggreggators of a decentralized alternative exist, and still be labeled a social outcast and a conspiracy theorist. It's not a technology problem, rather it's one of imbeciles.

It also exists on HN. There is a bevvy of topics we are not allowed to discuss here because dang will point to some arbitrary guidelines saying how "that's not allowed here" and ban you. It's the same shit everywhere.

Basically, the moment you step outside of the given narrative and what is and isn't allowed to be questioned, you should have zero (or less than zero, actually) expectation of having a platform where you can voice your concerns, and heaven forbid that your online persona be linked with your personal details, because if it is, you are in so much deep shit it's not even worth it for most people to utter certain words.


I once posted a question about some trans issue on multiple online communities. I forget the exact issue, and I presented both sides of the issue and then where I thought the truth may lie. I was pretty open about not knowing and wanting a discussion. It got shutdown everywhere, so I live on in ignorance because some things are apparently verboten. How does that benefit anyone?

There should be nothing so sacred as to be above debate.

The problem with this group of tech companies deciding what is true and what is not, is that even if they're right the vast majority of the time, that few percent where they were wrong and silenced that voice actually matter. Nearly every idea we now hold sacred in science was once heretical. If you silence the heretics, how can you have progress? The Catholic church used to do that, during a period we now call the dark ages. We know how this ends.

Protecting people from misinformation can't be done with censorship, only by presenting them with the truth.


You realize the reason being that Facebook users jump from “virus was leaked from a lab in China” to beating up Chinese-looking people a bit too eagerly. This is why I’m not that much concerned about Facebook rules in this case. Getting expelled from scientific community for not sticking to the most convenient hypothesis is another matter, much more serious.


Not only that, but the originally deleted articles were about an intentionally created and released bioweapon, not an accidental lab leak.


Nice bioweapon, barely kills anyone conscriptable. More like an evil pension system relief tool.


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There are plenty of more neutral and thoughtful comments taking the side of the lab leak theory that don't end up in a downvoted or flagged state. The GP comment obviously broke the site guidelines, for example with gratuitous flamebait.

https://news.ycombinator.com/newsguidelines.html


Yep... we should really have a debate about platform-vs-publisher status of media.



There's no legally spelled out condition, but one editorializes content and the other is content agnostic.

The justification of 230's existence is that the host shouldn't be liable, because it's not their speech.

That's no longer true if they're picking and choosing what gets heard, what gets buried, and what gets banned.

They may not be typing the post, but they're determining what actually gets said. And that means they no longer deserve 230 protection.


> The justification of 230's existence is that the host shouldn't be liable, because it's not their speech.

> That's no longer true if they're picking and choosing what gets heard, what gets buried, and what gets banned.

No, its not. That's approximately the traditional justification for distributors having more limited liability than publishers.

Section 230 was expressly adopted to allow platforms to act like publishers in a limited way without publisher liability, specifically to pick and choose what gets heard, what gets buried, and what gets banned.

The justification you invented is basically the opposite of the explicit purpose of 230.


>specifically to pick and choose what gets heard, what gets buried, and what gets banned.

BS. It covered liability for third party speech. It allowed controversial things to be said without the host being liable for hosting them.

Private censorship of controversial speech is the complete opposite of it's purpose.

>"No provider or user of an interactive computer service shall be treated as the publisher or speaker of any information provided by another information content provider"

If you only allow speakers to be heard that agree with you, you are the speaker.

If you only publish things that you agree with you are a publisher.

The law shields hosts in exchange for providing a place for free speech. If you no longer provide that space, you no longer deserve the protections it affords.

The behavior we see now is exactly the behavior that 230 was meant to prevent: sites being overly protective and aggressively policing what gets posted. 230 was passed so they wouldn't have to do it. It's not an excuse for them to do it anyway.

No one forsaw that the hosts would actually want an excuse to censor users.


> It allowed controversial things to be said without the host being liable for hosting them.

That was already allowed, provided they didn't, to use the phrasing being used in this thread, “pick and choose what gets heard, what gets buried, and what gets banned.” Doing that even on a limited basis made them, under pre-230 law, a publisher, subject to liability for all content on the platform.

Section 230 was adopted specifically to allow platforms to moderate user-generated content according the platform owners’ view of objectionable content without incurring publisher liability, because the pre-230 situation was viewed as encouraging a situation i which platforms who didn't feel they could completely moderate were forced to not moderate at all, making online communities persistently polluted with objectionable content.

The Communications Decency Act, of which 230 was the only substantive part to survive, was not about promoting unmoderated internet fora, but the opposite.


Choosing speech to be removed doesn't make it your speech. If at a city council meeting you're not allowed to yell and be inflammatory - is it now the cities speech when they tell you to get out? No.

If they tell you, "you can't say that, change what you're saying" is it now the cities speech? No.

230 specifically is for the purpose of not being liable, and being able to choose what's on your platform. Specifically so you can moderate your own platform.

No one has some magical right to use your social media business.


This is the way you think the law ought to work not how it is in fact written.


>"No provider or user of an interactive computer service shall be treated as the publisher or speaker of any information provided by another information content provider"

That's how it's written. It provides protection for hosting controversial content posted by users, based on the fact that the host didn't write it, endorse it, or promote it.

If the host has an active hand in doing those things, they are no longer merely hosting. Same goes for surpressing or censoring.

The "another content provider" means the host is not involved in determining the content. But treating posts differently based on that content is not meaningfully different than an editor choosing what to publish.


There is no clause matching your assertion in the rather short law passed 25 years ago and no case law asserting your erroneous interpretation. I'd ask you to provide such but we both know there is none. Neither editorial selection nor removal has anything to do with 230 immunity. The law is working as written and intended.

It isn't merely a grey area. The law was deliberately intended to support editorial selection and even deletion of content offensive to the platform owners sensibilities while explicitly preserving their protection from liability for their users content. This is supported by a plain reading of the text and the words of the men who wrote it.

First the law

https://www.law.cornell.edu/uscode/text/47/230

> No provider or user of an interactive computer service shall be held liable on account of—

> (A) any action voluntarily taken in good faith to restrict access to or availability of material that the provider or user considers to be obscene, lewd, lascivious, filthy, excessively violent, harassing, or otherwise objectionable, whether or not such material is constitutionally protected; or

>(B) any action taken to enable or make available to information content providers or others the technical means to restrict access to material described in paragraph (1).[1]

Now the words of Ron Wyden

>Republican Congressman Chris Cox and I wrote Section 230 in 1996 to give up-and-coming tech companies a sword and a shield, and to foster free speech and innovation online. Essentially, 230 says that users, not the website that hosts their content, are the ones responsible for what they post, whether on Facebook or in the comments section of a news article. That's what I call the shield.

> But it also gave companies a sword so that they can take down offensive content, lies and slime — the stuff that may be protected by the First Amendment but that most people do not want to experience online. And so they are free to take down white supremacist content or flag tweets that glorify violence (as Twitter did with President Trump's recent tweet) without fear of being sued for bias or even of having their site shut down.

Your positions isn't merely incorrect it is directly counterfactual. It's an example of replacing actual known reality with the counterfactual in order to obtain a rhetorical advantage.

It is more advantageous to start from the lie that platform owners have somehow been violating or abusing the law outrageously and something must be done about it compared to the actual reality that the law is working as intended and you wish to change it because there is both a general feeling that existing laws and privileges ought to be enforced and that new laws need be examined before being enacted.

The prevalence of people of a particular political stripe to literally just making up alternative facts in response to inconvenient reality is deeply challenging to productive dialogue because its impossible to start out with a reasonable basis for discussion one must instead rewind to figure out which part of your fellows assumptions are based on purely fabricated reality. I expect you have taken it as a given that the line you were fed was based on reality. You are mistaken. I strongly encourage you to read both the laws and the words of the man who cowrote it.


>obscene, lewd, lascivious, filthy, excessively violent, harassing, or otherwise objectionable

The intent is clear from this list. It even implicitly allows violence as long as it's not excessive. It does not include anything about truth, or difference of opinion, or statements that aren't "backed by the science".

It also requires a "good faith" interpretation, which would be irrelevant if hosts were allowed to act on any criteria they wish.


Otherwise objectionable is so broad a fig leaf it could shade a continent. Just because they called out excessive violence does not mean a platform need tolerate any violence.

Good faith is only relevant to immunity from suits by people whose content was moderated not in terms of liability for other parties communications which is inviolate in all cases.

A finding of bad faith would then pertain exclusively to the particular act or acts of moderation and would not effect the platforms immunity for either other acts of moderation or for other parties speech. There is no act by which a companies 230 protection may be in general dissolved.

Furthermore absent 230 protection for act or acts of moderation those moderated would have little just cause to bring anything but fraudulent frivolous lawsuits because you in truth have little right to be heard on someone else's website. That is to say finding bad faith would only open the door to lawsuits it wouldn't be a cause in and of itself.

Say I banned you from my site because I don't like blond people but lied and said it was for breaking site rules.

I might be acting in bad faith but as you have no particular right to access or post content on my site so the judge would find my bad faith may cost me protection under 230 but nothing else.

This is probably why there wasn't a notable finding of bad faith that helped the blocked party between 1996 and 2019.

In 2019 we finally had Malwarebytes v Enigma wherein Enigma sued Malwarebytes labeling it's software as a possibility unwanted program and advising it's users not to install it. The 9th circuit found it was in bad faith discouraging competition.

If your issue is Facebook and Twitter silencing some viewpoints this is hardly encouraging as there are few parallels.


They want to have a discussion/debate on what rules should exist. Just because there aren't current rules doesn't preclude us from making some....


But it should be.


Because people are sharing actual conspiracy theories and killing others. So it's a blanket ban. How many people are so crazed and convinced that the vaccine makes you magnetic/sterile/whatever?


Lots of things killed people last year, including the lock down. Being allowed to criticize things like that is what separates us from countries that lack democracy.


Germany has certain very strict policies about whether you're allowed to discuss certain things, and they outrank the US by 30 positions on the World Press Freedom Index[1]. Sometimes you have to suppress bad actors who willfully push unverified or outright fallacious information in order to have actual freedom of information.

[1] https://rsf.org/en/ranking_table


Let us not use Germany as an example of a place that justifies regulating speech. That particular quirk of German jurisprudence has so much baggage behind it, it really isn't worth bringing to the conversation.


Suppressing criticism of the government should always be considered unacceptable. Doing so trivially allows some nasty social pathologies.


Not very many


Conspiracy theories are not harmful that kill people. This is an idea the media spread in the last little while to label non-approved opinions as harmful.

Facebook decides to blank ban anything that hasn't been approved by gatekeepers and you approved because you are worried that people might hear on facebook that vaccines cause people to go sterile and not get one?

Which one of these things is actually causing harm? Shutting down all discussion or the worry that someone might post and might think the vaccine causes you to be magnetic?

It's crazy people are falling for this.


It's not that they "might hear" it's that people in mass already believe in made up propaganda about coronavirus vaccines. The natural result being individuals at risk not getting them, and individuals not as at risk not getting them, resulting in more death and longer lockdowns.


I grew up reading conspiracy theories, then met powerful people and realized (20 years ago) that conspiracy theories were implausible.

Then I worked with the IC and heard what intelligence agents said. Maybe they lied. Maybe they’re crazy. But combined with what happened in the last 18 months, and their statements, there is an acutely centralizer corrupt power which has ever bigger rings of corruption.

Which is normalized as it goes. Everyone does it! Politics as normal. Modern Neoliberalism and government revolving door.


If you say someone committed murder with zero evidence to back it up it's wrong-- at that time-- even if evidence ends up coming out. You still had no basis for such a serious accusation and would still be irresponsible to throw the accusation around as "true".

Sometimes people make unfounded guesses based on little/no evidence. Just because it turns out to be correct doesn't mean those people were any more justified-- at that time-- in their unfounded accusations.

Of course a person is now justified, with evidence available, to make these claims. It doesn't mean those who made them baselessly out of suspicion and guesses any less irrational for doing so before there was evidence. Making unfounded accusations doesn't retroactively turn an irrational accusation into a reasonable one just because it turns out to be true.

It's also worth noting that this is still unproven: it doesn't look good for China, but there's nothing definitive yet.


Actually I knew about Shi's work early on because I talked with experts on the field and I shared all this info without problems.

The urge to ban that info in social sites came much later, when politicians got the message and considered that info dangerous(and because the West depended on Chinese supplies).

Most politicians are so dumb from the scientific and technical side that it took a long time for them to understand.

But it gives us and important lesson: If we want to inform ourselves, we should use alternatives to centralized social media.


I don't think you need to make conspiratorial allegations about the info being judged "dangerous" to explain it.

It simply got politicized just as masks got politicized. The more one side advocates it the more the other side discredits it.


Except in this case, the left tried to discredit it.

If Trump kept his mouth shut, it may have gone down differently (that is, less politicized).


Trump saying something should have no bearing on whether it is true or whether it deserves consideration by the public. I see this as the media over-reacting to Trump (and to Tom Cotton) and now they have egg on their faces.


That's because Facebook is full of bad actors sharing actual complete bullshit conspiracy theories, and the only thing a company like Facebook can possibly do is a make a "nothing that deviates too hard from the Official Line(tm) rule." Otherwise they have to get into the business of being some kind of scientific review board, which they are in no way equipped to do.

Bad faith propaganda at the scale we have seen recently is abuse of free speech, and widespread abuse of a freedom often leads to the curtailment of that freedom.


That crazy shit is only a problem because they built an algorithmic feed that automatically finds the most virulent bullshit, and then shows it to everyone it possibly can.

Drop the algorithmic feed, and you solve most of the problem. Unfortunately for Facebook, this would also cut their ad revenue, so they'll never do it.


Official line in which country? And what happens when the WHO says one thing, the CDC says something else, and the President contradicts both?


What happens? Facebook eats it from all sides.

I didn't say they were doing a good job, just that the alternative would have been to let the platform turn into a complete cesspool of bullshit and hate.

This scenario is a curse you get when you are operating a gigantic Internet forum at that kind of scale.


> I didn't say they were doing a good job, just that the alternative would have been to let the platform turn into a complete cesspool of bullshit and hate.

Here's an example of this happening[1].

[1] https://www.nytimes.com/2018/10/15/technology/myanmar-facebo...


> Otherwise they have to get into the business of being some kind of scientific review board, which they are in no way equipped to do.

They're not that far off that to be honest - https://oversightboard.com/


It really doesn't make a difference if covid came from a lab or not, or even whether it was released on purpose or not. No one will stand up to China whether they did this on purpose or by gross negligence. So no one will stand up to China. So nothing will change...


Could China have handled this better? Hell yes.

The thing is though, I seriously doubt the end result would have been any different if the virus has first come about in any other country.

Imagine that the virus has first been discovered in Atlanta (first US city that came to mind) - would officials really be brave enough to have a hard, immediate lockdown, with all the economic hardships that would entail, and with all the problems of getting a doubting populace on onboard? (keeping in mind that Trump's initial reaction was to denounce the very notion of a serious virus as a "hoax")


> would officials really be brave enough to have a hard, immediate lockdown

To ask the question is to know the answer. Just imagine a public health official trying to convince the mayor or governor to quarantine a city of millions of people, based on a small number of pneumonia cases.


I wasn't really referring to their reaction to covid, rather their creation of covid.

Leaving aside the Lab origin theories, Covid 19 never would have happened if China had hygienic food supply-chains and banned wet markets.

That's where other zoonotic diseases have come from in recent years from China (SARS is the biggest example). They closed the markets, new viruses stopped happening and everything was fine. Then they opened the markets again and we got covid 19.

China is like a drink driver who already hit someone and refused to stop drunk driving and hit another person. Right now no one wants to make them stop driving. So I guess we'll just keep getting pandemics?

Covid 19 is really just SARS 2.0.

That's what really gets me here (sorry, I'm ranting now). China knew this would happen. Everyone did. And they did it anyway. And now everyone is pretending like it was bad luck or something!? This is literally why every other major, industrial country has food hygiene laws and minimal "Bush meat".

Thanks for listening to me shout into the wind.

https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndr...

Edit: I wonder if one of the reasons china is so unwilling to engage is to encourage people to think it was a bio-weapon accident (we'll never stop that happening) rather than just "the CCP is too weak and lazy to say no to old people who want bat soup". Conspiracy within the conspiracy! But I'm an idiot so probably not...


Better yet, it doesn't matter because supposedly we're spending billions of DoD to actually have plans to defend against a bio weapon attack.

Where is the RoI on that? We failed miserably.


Like the majority of DOD spending, all promise and no delivery. We're still building aircraft carriers while hackers cut off the utilities...


The article is specifically discussing concerns with us funding of this sort of research. That is something that can change.


If it makes no difference, why obstruct investigations and attempt to conceal data? [0] [1]

Why not simply collaborate and cooperate with the authorities in finding the truth? After all, they are 100% convinced the origin of the virus is natural...

[0] https://www.newsweek.com/china-calls-us-investigation-covid-...

[1] https://nypost.com/2021/06/04/chinese-virologist-says-fauci-...


All I know is I want better lab safety and more gain-of-function research!


Considering how academia has acted so far in regard to the SARS-CoV-2 origin question—most ardently anti-lab-leak scientists ridiculing alternative viewpoints, then turning out to work or have friends working for an organization pulling millions of USD in grant money on related research—it is difficult for me to take its publications on the topic at face value anymore.

For a take published outside of academia, there’s been a thought-provoking write-up featured here not long ago[0]. It touches upon the funding aspect that this article focuses on, as well as the contrived web of misinformation around the issue, WIV virus sample mislabeling, the apparent PLA’s involvement in US-funded research, and a lot more.

[0] https://news.ycombinator.com/item?id=27388587


Not to miss the 2nd part of the video. Chinese threat is not about china. But the censorship of deliberation. May be the lab theory is wrong. But not allow to talk and discuss about it … that is how learn from the current 7 million social experiment of transforming a liberal society here in Hong Kong to one sanctioned. Good luck USA. It is so ingrained in USA can you save yourselves. Good luck humanity.

It is not just about a lab leak. It is the deliberation and freedom of expression that is more than important. Good luck.

Humanity has lost. It might come back. After losing hundred years perhaps. But why we do not wake up and start to rebuild a better open environment … so we can be safe later.


People will hate this source, but this is the most info I’ve seen revealed about the actual conditions in the Wuhan lab(s):

https://www.the-sun.com/news/3174242/wuhan-labs-leak-covid-c...


That's because the source regularly deliberately misinforms. So it's impossible to know if literally any of the claims here are completely made up.

For example:

_In December 2019, The Sun's political editor, Tom Newton Dunn, wrote an article for the paper titled "Hijacked Labour", alleging that "Jeremy Corbyn is at the centre of an extraordinary network of hard-left extremists pieced together by former British intelligence officers", a network ranging from Novara Media contributor Ash Sarkar to French philosopher Michel Foucault, who has been dead since 1984, that is alleged to be pulling Corbyn's strings.[204] It was later found that the ultimate sources for this claim included the antisemitic, far-right websites The Millennium Report and Aryan Unity._ [1]

https://en.wikipedia.org/wiki/The_Sun_(United_Kingdom)#Far-r...


[flagged]


I'm not understanding the case you're making. The most notable action by the NYT on yellowcake (the main citation in the Wikipedia article) was publishing the op-ed by Joe Wilson indicating that the evidence that Iraq was trying to buy yellowcake was forged. To me, that story has considerable resonance with the lab leak theory, in both cases certain factions within US intelligence trying to push the theory hard, and releasing "evidence" through indirect sources that cannot readily be verified. In the lab leak case, a major part of that role was played by the Wall Street Journal, which published the account of 3 Wuhan lab workers hospitalized in November 2019[1]. The part of Joe Wilson basically being played by Christopher Ashley Ford, in a letter cited elsewhere in this thread.

[1]: https://www.wsj.com/articles/intelligence-on-sick-staff-at-w...


This is whataboutism, as well as ad hominem.

I accurately stated that a source was not a reliable one (it’s a British tabloid, my nan who survived the war knows this but I provided an example of evidence).

> hN is just full of highly propagandized group thinkers.

Rationalism and evidence.


The 60 page report that's listed halfway through isn't peer reviewed, and the main author only submits papers about the wuhan lab. It's also on researchgate, which is about the same as saying someone publishing a study on twitter.


If you want to know the actual conditions, there is a recent article from a much better source

Bloomberg: The Last–And Only–Foreign Scientist in the Wuhan Lab Speaks Out

She is an Australian virologist, now working in Melbourne’s Peter Doherty Institute for Infection and Immunity, previously scientific director of the biosafety lab at Singapore’s Duke-NUS Medical School in 2016.

Archive link:

https://archive.is/IFDZY


I read that and her volunteered info was all over news sites last week. However, this is not what we need. What we need is an independent body that goes into the Wuhan lab.

Let us inspect the bats. The cages, the equipment, the staff.


It seems unlikely to me that a team going to the lab now would be able to tell us anything at all about how the lab was operated 18 months ago. The chances that it hasn't been completely gutted and re-worked from scratch by now seem to me to be precisely zero. The window of opportunity to get a team in there and actually find out what was going on closed probably in late January or early in February 2020.

Meanwhile we have someone here with direct experience of the lab as it was at the actual time in question. It seems to me that's absolutely the best we are ever likely to get.




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