Browsing in a VM is really one of the only safe ways to go on the modern web for privacy. So many sites break without JS, and having it enabled is an accident waiting to happen.
When you need privacy, always browse in a VM or a Tails boot.
Even in a VM you have to carefully ensure that memory deduplication is disabled, and/or some form of mitigation against Rowhammer is in place. Else you will be vulnerable to Flip Feng Shui cross-VM attacks.
This won't work against fingerprinting unless you change the underlying hardware and / or external IP too when stating a new VM. If you don't have a unique external IP per VM you might as well not bother. It is like trying to hide from the police by changing clothes and cutting your hair but stil hold the same huge sign with your name and address in your hands.
Since this is about fingerprinting and not hiding your identity I'm not sure this will help. If you use a public VPN you are removing some data points from the fingerprint but adding a huge new one. After all fingerprinting is about blending in and being like the average user. Adding a few privacy extensions and a VPN and you are much easier to recognise.
When you need privacy, always browse in a VM or a Tails boot.