However, if it does work in humans it’ll be a huge leap forward for treatment of auto immune diseases. Perhaps long term, even inflammatory issues like arterial plaque, which we’re slowly realizing is formed by chronic inflammation as much as by high cholesterol. Alzheimer’s May also be largely driven by incorrect immune responses too.
I suspect the challenge will be long term mRNA suitability, e.g. if the mRNA delivery mechanisms will develop immune reactions of their own. The cost of delivering the mRNA treatments could be large too. Biologics for autoimmune conditions require self administered shots too, but don’t require deep freezer cold. Also it could increase long term cancer risks by over stimulating self-regulatory pathways.
Not sure if the full article mentions if it’s a one time shot or on going. I’m presuming ongoing dice mRNA will degrade.
Though for this specific vaccine the question is somewhat irrelevant. In this case, they are introducing an antigen that the underlying condition, MS would never cause to occur. This antigen activates regulatory cells which then supress the immune systems production of myelin targeting antibodies.
So in the case eof a normal vaccine, regardless of whether it is mRNA or not, the vaccine is conveying information to the immune system that you might also acquire through an active infection.
This vaccine however is conveying information to your immune system that no active infection would convey.
This all kind of answers my own question which would seem to be yes. As long as they can find an autoantigen that will stimulate regulatory cells which supress the problematic autoantibody producing immune cells. At least that is my read after mucking through the medical jargon.
mRNA is tech that BioNTech is developing is completely digital. Once you have the RNA structure in the computer, you can just "print out" drug/vaccine using the same process without changing anything else.
(1) - https://science.sciencemag.org/content/371/6525/145
Some cells in the body present features that teach the immune system that these features are 'OK' and part of the healthy body and shouldn't be attacked.
This therapy seeks to cause those cells to produce features, or produce more of some features, that are being incorrectly recognized as 'bad' by the immune system. Thus correcting the immune systems 'understanding' and suppressing mistaken attacks on the body which underlies auto-immune disorders.