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There's an interesting book called "Who Goes First?"[1] about something that used to be much more common than it is today: self-experimentation in medicine.

[1] - https://www.amazon.com/Who-Goes-First-Lawrence-Altman/dp/052...

Ethics is great and all but makes it hard to do much original research. This sounds crass but try getting a very routine IRB proposal passed, and you'll see what I mean.

Self experimentation remains relatively out of reach of the ethicists and so should be kept in mind for the more creative researcher types.

Yes, amen. And what better reason to have children than to have accessible human subjects?

Preferably twins, so you can have a control group.

See also, an old story by Scott Alexander: https://archive.fo/eSbZb.

Hadn’t heard of this. Just got a used copy for myself through Bookfinder!

Hey... Thanks for mentioning Bookfinder. Seems like a great resource. I ordered a copy myself as well. :)

This. 20 years on the internet and right now is when I first learn of Bookfinder, which looks like a wonderful resource. Just like HN, where I was just reading and learning from the comments on this remarkable self-operation when, like you, I serendipitously stumbled on Bookfinder. HN is one of the few places online where I can count on finding an unexpected wormhole into a different knowledge universe. My favorite website of them all.

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