Youngme Moon, in her book "Different", offers the idea that one should say Yes where others say No, and No where others say Yes to produce meaningful difference. Once you go this way, you iterate and improve on the ways you say Yes to accentuate the difference. There are similar suggestions in other recent books on differentiation (Moore's "Dealing with Darwin", for example)
Look at all the ways Clojure says Yes, where other lisps/languages have said no. Being a lisp, embracing the JVM, immutable by default and everywhere, first-class concurrent primitives -- clojure should probably say No if it compromises these core goals. It should say YES when it furthers these tenets.
I don't use it enough to really understand Yegge's gripes, but the best move for clojure is probably to make these things possible as libraries if it doesn't want to embrace it in the core, and iterate on the core so that it's the only possible choice when you are in the situation that requires it.