* no skills for their new environment
* no money
* billions of warm-bodied, warm-blooded other humans already there
* suffering from lonliness knowing everyone you've ever known is dead
Unless the defrosting process is great and there's going to be gene therapy, and it won't be for maybe the first few hundred/thousand people, you'll be disabled, diseased or still suffering from whatever killed you in the first place.
"The body of B. Franklin, Printer (Like the Cover of an Old Book, Its Contents torn Out And Stript of its Lettering and Gilding) Lies Here, Food for Worms. But the Work shall not be Lost; For it will (as he Believ'd) Appear once More In a New and More Elegant Edition Revised and Corrected By the Author.
" --Benjamin Franklin (self-authored epitaph)
Edit: updated to show his final version.
I'm only half-joking.