Judging from the exploded view, it looks like the side-panel has a simple latch, and other parts (including power supply) have tool-less access as well.
Here's a video of the case I used in my last build, released 2017.
The side just latches off with minimal effort, this feels even more accessible than having to pull the entire cover off. Both the define r6 and the mac pro have extra steps to get to additional components, like the latch to remove the memory cover on mac pro or the latch to access the top fan mounts on the define r6.
