Ad blocking is the first thing I install on a new device.
It's a revenue source for the content creators.
Right now I run a Pi-Hole for my entire network, and on Firefox I use Clear URL, Decentraleyes, HTTPS Everywhere, Old Reddit Redirect, Privacy Redirect, and uBlock Origin, configured to block third-party fonts, and JS as well — which I whitelist when needed.
When I just want to read something, without having any form of interaction with the page, and I know it works well, I usually just use w3m on the terminal, which I found out because of aerc. Pretty cool browser for the terminal.
Am I super duper secure because of all these hoops I jump through? No. But it does not get in my way, and make me enjoy browsing the internet again, so why not?
 I have it set up on a dedicated server with Hetzner, with the server itself being the DNS provider for Pi-Hole using DNSCrypt.
 https://github.com/tom-james-watson/old-reddit-redirect — not really privacy, or blocker related, but I find the new Reddit interface a dumpster fire
I don't really do it for privacy reasons, I use Temporary Containers in Firefox for that.
On a related note, this makes me wonder how many people both run ads on their own sites and use adblockers at the same time. I'm certainly guilty of that one, and I wouldn't be surprised if the people running these media sites and social networks were in the same situation.
I have had very restrictive quotas while travelling (2 gig per month, = 60 megabytes per day!) and to have a large proportion of your daily allowance being taken up with megabyte after megabyte of unnecessary downloads is a pain.
And that's apart from the clutter of unwanted crap that's scattered all over your browser screen.
I use NextDNS + AdGuard, which filters out a good 99.5% of shit.