You can already buy lasers off Amazon or Aliexpress that can set things on fire. I'm giving it 10 years tops before we have lethal man-portable laser rifles.
Even with smoke, it's a pretty good bet that the total thickness of smoke particles in the path of the beam is less than that of a coat of paint. No problem for a 150 kW laser to cut through.
Let's say if a mirror can reflect 99% of the light that hits it, and we shot it with 1kw laser. That means 100w is still heating the mirror and it might melt or shatter it.
Plus, depending on how much control the attacking drone has, that's also 99% of the beam being deflected back at the ship with the laser.