Hacker News new | past | comments | ask | show | jobs | submit login

the problems with Purdue/oxycontin was their false and extreme marketing that falsely claim lower/tiny addiction rates, bribing doctors to prescribe, claiming 12 hour relief when many users got 8 hours, and the list goes on. perhaps a misleading shorter half-life could be 'more addictive' in that users took more than prescribed to keep effect going.

In general there seems to be a rule of thumb that shorter half-life drugs are more addictive - they hit you fast and wear off fast.

Within the same category of drugs, e.g. Benzodiazepines, it's pretty well established that the first step towards getting clean is to get the dose of low half-life drug swapped out for an equivalent dose of a long-acting drug, then taper down from there.

I believe this is also the theory behind the use of Subutex/Buprenorphine and Methadone as ways to get people off heroin and oxycontin.

So conversely, if Oxycontin had a shorter half-life than was advertised then one would expect it also to have a worse addiction profile.

Guidelines | FAQ | Support | API | Security | Lists | Bookmarklet | Legal | Apply to YC | Contact