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Does this relate in any way to the anti-aging drug cocktail that we saw a few months ago?

IIRC that one related to genetic aging markers, and stress can affect mitosis.

It seems like immortality has a lot of building blocks, and the research isn't far enough to combine them yet.




Here is the Nature article with a link to the study in the footnotes.

https://www.nature.com/articles/d41586-019-02638-w

This blog post has commentary on the study. If you are interested in the topic, consider suspending disbelief until after reading the post. It does a great job of clarifying what the evidence actually shows, and outlines one way to contextualize this intervention.

http://haidut.me/?p=546


Anyone have a link to that? Sounds interesting.


You should watch Joe Rogan speak with David Sinclair, who researches aging at Harvard, about the latest developments in his field https://youtu.be/ZGLL77wYxe8

Aside from multivitamins and idiosyncratic drugs, Sinclair takes the following supplements every day:

- Resveratrol – 1g in the morning (this is synergistic with NMN)

- Nicotinamide Mononucleotide (NMN) – 1g in the morning

- Metformin (prescription drug) – 1g in the evening – except on days when exercising, since metformin reduces muscle growth after exercising

(As an aside, he also engages in intermittent fasting, to reduce his total feeding hours. There’s a theory that intermittent fasting triggers a beneficial stress response whereby your body becomes more “efficient” in a way that prolongs life. Intermittent fasting has been shown to prolong lifespan in mice. Interestingly, resveratrol is expressed in plants as a defense mechanism akin to what intermittent fasting does in humans, and that’s one of the supplements that Sinclair recommends.)

Sinclair is very careful not to recommend that cocktail for anyone, since anti-aging research is still very preliminary. The relevant human trials are underway. However, NMN in particular has had astonishing effects on mice. Mice that took NMN lived significantly longer than other mice. Old mice that took it ran for so long that the measuring device on their running wheel timed out, because they weren’t expected to ever run that long.

In old age, the NMN mice were conspicuously stronger, had more hair, saw better, and were more mentally intact. In short, NMN might reverse the underlying epigenetic causes of aging. Sinclair subscribes to the information theory of aging, where, over time, your epigenome accumulates damage and errors, and protective mechanisms die out. It’s like scratches on an overplayed analog vinyl disc which slowly declines in function and eventually stops playing altogether. You lose a majority of your NAD+ as you get older (NAD+ is fed by NMN), which is problematic because NAD+ feeds biological mechanisms which mitigate informational damage. That’s why supplementing with NMN is theorized to have anti-aging effects.

Sinclair wrote a great book synthesizing aging research if you want to read more about it. https://www.amazon.com/dp/1501191977/ref=cm_sw_em_r_mt_awdo_...


Re reservatol:

The jury is out in terms of its efficacy, or lack thereof. [1,2]

[1] https://www.health.harvard.edu/blog/resveratrol-the-hype-con...

[2] https://www.health.harvard.edu/blog/diet-rich-resveratrol-of...

Re. David Sinclair [3]:

"Despite his enthusiasm, published scientific research has not yet demonstrated the molecule works in humans as it does in mice. Sinclair, however, has a considerable financial stake in his claims being proven correct, and has lent his scientific prowess to commercializing possible life extension products such as molecules known as “NAD boosters.”

His financial interests include being listed as an inventor on a patent licensed to Elysium Health, a supplement company that sells a NAD booster in pills for $60 a bottle. He’s also an investor in InsideTracker, the company that he says measured his age."

[3] https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-...


Yep, resveratrol on its own doesn’t seem to do much, which is puzzling given its effect on mice. That’s why I added Sinclair’s claim that it is a synergistic part of his drug cocktail. Let’s hope NMN is different. As for Elysium, Sinclair is not affiliated with them and he said he doesn’t make any money off of supplement sales.


hopefully it doesn't turn out like the book of that sleep guy, matthew walker

https://guzey.com/books/why-we-sleep/


Walker seems to have made some claims without empirical backing. Sinclair on the other hand refers to miracle research in mice and says that they might or might not translate into humans. However, he does explain, at length, how it may work to extend longevity in humans just like it does in mice.

He also gave the aforementioned drug cocktail to his elderly dad and said it seems to have rejuvenated him. His dad is hiking all around Australia, just like he did as a young man. I paid little attention to that particular claim since it is an n=1 anecdote.


I’d like to read as well.




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