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A big issue is its actually expensive to start a company that involves lab. Software can genuinely be one person in their bedroom with some AWS credit. I think the "why has no one else done this?" question is one of the worst anyone in the history of business or science can ask themselves. Any opportunity looks like that, it's why its an opportunity! The very best ones look like an obvious gaping chasm when you see them.

I'm in agreement with that sentiment. For any given opportunity, even if it's "obvious" that someone should have done it, doesn't mean it's been done before. If something seems like an opportunity you should probably try to validate it, instead of immediately discounting it. That's how I started my last company!

But there's no doubting that some sort of counter-intuitive or hidden insight is necessary. Even if that insight is: "people think this is obvious and not worth doing, but it actually IS worth doing." RE: Zero to One.

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