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For the most part, you wouldn't use the web interface, which exists mostly for archival/search-engine purposes. You use a plain email program, and get used to hitting "reply all" instead of "reply" (this will have it be "To:" the person you're replying to, and will "Cc:" the mailing list address), you send a regular email to the mailing list address when you want to start a new thread. A halfway decent email program will thread the replies, like HN does.

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