Of course the problem is the reliability of the evidence. I recently had to decide whether I wanted to go on a course of some fairly severe drugs with nasty side effects.
The original papers didn't make a lot of sense. The statistical conclusions seemed to be - if not nonsense, then certainly not very consistent.
My doctor said "Well, these are new drugs, so we're still learning about them." I didn't find that reassuring.
The real problem is that big statistical studies don't say much about why side effects happen. There seems to have been far too little research into understanding why/how side effects happen at all, and whether or not it's possible to screen for them.
That would probably require a level of personalised medical screening and dose control that big pharma isn't interested in providing.