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Probably from oxidative stress which can be caused by psychological stress, poor diet, lack of exercise, social stress, smoking, irregular blood glucose, viruses and bacteria, etc. Pretty much the already known risk factors for heart disease.



But more importantly they die from normal processes required for life, so even without risk factors after living long enough everyone would get heart disease. Probably this is why they do not talk much about cells dying and talk about the ways to revert the effect of their death. Aubrey de Grey often talks about this when telling about the SENS foundation.




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