It seems possible that the US will get itself into a conflict, possibly (hopefully!) non-total, that disrupts its globalised supply chains and results in massive US business losses. On the other hand, it's hard to see what any non-nuclear opponent could do to the US that would be more damaging than its own opiate manufacturers have already achieved.
Before WW1 happened, people thought there was no way a major war in Europe, entangling the major powers, would happen because all of their economies were tied together and it would result in a major economic collapse. However, the war still happened.
Granted the circumstances can still set the stage afterwards for future conflicts even if the fools responsible lost power as unfortunately demonstrated by WW2.