One can have a traditional loving partner, a traditional family, a traditional social circle and still be lonely.
One could feel isolated from their peer group because of happenstance and life choices leading to different economic outcomes.
One could feel isolated from their gender; no only because it is a social construct, but because the ones that represent you act like morons all the time.
One could feel isolated from a sibling because they are ill and can't afford healthcare.
One could feel isolated from themselves because they are have chronic pain or mental illness.
Blaming societal ills on one or two issues only divides further and obscures the macrocosm. If you want your 2.5 kids and a picket fence, godspeed, but don't step on others trying to find what makes them happy.