If you work with the sender or if they are your friend, or otherwise are known to you - then yes. I'm obviously obviously not talking about replying to spammers here.
In my book, “Hello?” deserves no answer and I'm very fine with whoever sends that not willing to send me more emails.
The previous emails might deserve an answer I just haven't had the time to send yet, but for otherwise equally important emails, the one from the most annoying / disrespectful sender will be handled last, if ever.