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The big issue that AB/hyperTau studies seem to studiously ignore: studies in human brains have found an inverse correlation between the sites of the brain with excess plaque formation and the sites of the brain with the most significant atrophy and functional decline.

This is unsurprising, given the last two decades of drug trials targeting these molecules have all uniformly failed.

The alternative hypothesis is that these plaques are protective against neuronal infections that provoke alzheimers. That hypothesis has not garnered wide support yet, though it is growing, and is at least consistent with the inverse relationship observed.

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