Sure you can. Even with the new $750k cap, and if you assume a (very low; chances are it's higher by a factor of 1.5 or 2) rate of 2%, you can get to $15k.
If you assume a 4% rate, then you get to $14k with a $350k mortgage. In various coastal-metro markets that's basically an entry-level house.
The other common itemized deduction is charitable contributions. Unfortunately, I see lots of "average" data for those, when what would be most useful here is median data: the average is presumably heavily skewed by wealthier or higher-income taxpayers. But as an anecdote, I know multiple people who drop $20 in the collection plate every week when they go to church; that's ~$1k right there.
Thanks -- I hadn't done the math, and was mostly grumpy about my mortgage interest + SALT not being enough. No significant charitable donations this year, I bunched up with a DAF in tax year 2017 for several reasons.