According to Alan Kay, Smalltalk was an explicit attempt at making something as dynamic as Lisp, but where one wasn't "coding in your data representation." There was very high representation in the Fortune 500, and some very big business applications. Much of the natural gas in North America was scheduled on a Smalltalk application. JP Morgan used Smalltalk to manage very large portfolios at one point. I could go on about the applications I know about personally for hours, actually.