The fact that transaction wrap around is so well-known is itself a red flag--apparently a lot of people have run into this issue, and yet it keeps being an issue. The blast radius is very large and the recovery is painful, as shown here by Mandrill. You should think twice before accepting that risk if you value your uptime.
If you want to become an expert on all these pitfalls and caveats of running relational databases at scale, at the expense of your availability and customer satisfaction--then by all means continue using relational databases. For many use cases, there are better options with better failure resiliency and recovery stories.